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15-acetoxy Scirpenol (Synonyms: 4-Deacetylanguidin,NSC 267030)

Catalog No.GC11988

mycotoxin that induce apoptotic cell death

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15-acetoxy Scirpenol Chemical Structure

Cas No.: 2623-22-5

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1mg
$293.00
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5mg
$1,170.00
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Sample solution is provided at 25 µL, 10mM.

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Background

15-acetoxy Scirpenol is a trichothecene mycotoxin which is produced predominantly by members of the Fusarium genus [1]. 15-acetoxy Scirpenol could induce apoptotic cell death in human Jurkat T cells. Mycotoxins of scirpenol belong to the trichothecene family which is mainly produced by the fungal species of the genus Fusarium. Acetoxylated scirpenol has very high toxicities in animals and humans. 15-acetoxy Scirpenol exhibited cytotoxicity at a lower concentration (25 ng/ml). The 50% inhibitory concentration (IC50) values of 15-acetoxy Scirpenol was 16.1 ng/ml [2]. In the Jurkat T cells treated with 50 ng/ml of 15-acetoxyscirpenol (15-MAS), the populations of externalized PS-positive and PI-negative cells were 32.0% [2].

References:
[1] Peraica M, Radic B, Lucic A, et al.  Toxic effects of mycotoxins in humans[J]. Bulletin of the World Health Organization, 1999, 77(9): 754-766.
[2] Lee D H, Park T, Kim H W.  Induction of apoptosis by disturbing mitochondrial-membrane potential and cleaving PARP in Jurkat T cells through treatment with acetoxyscirpenol mycotoxins[J]. Biological and Pharmaceutical Bulletin, 2006, 29(4): 648-654.

Chemical Properties

Cas No. 2623-22-5 SDF
Synonyms 4-Deacetylanguidin,NSC 267030
Chemical Name 12,13-epoxy-trichothec-9-ene-3α,4β,15-triol, 15-acetate
Canonical SMILES CC1=C[C@]2([H])[C@]([C@]([C@H](O)[C@H]3O)(C)[C@@]4(OC4)[C@]3([H])O2)(COC(C)=O)CC1
Formula C17H24O6 M.Wt 324.4
Solubility ≤10mg/ml in methanol;10mg/ml in dichloromethane Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 3.0826 mL 15.4131 mL 30.8261 mL
5 mM 0.6165 mL 3.0826 mL 6.1652 mL
10 mM 0.3083 mL 1.5413 mL 3.0826 mL
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