Home>>Signaling Pathways>> GPCR/G protein>> Angiotensin Receptor>>1H-1-ethyl Candesartan Cilexetil

1H-1-ethyl Candesartan Cilexetil

Catalog No.GC17757

selective angiotensin II type 1 receptor (AT1) antagonist

Products are for research use only. Not for human use. We do not sell to patients.

1H-1-ethyl Candesartan Cilexetil Chemical Structure

Cas No.: 914613-35-7

Size Price Stock Qty
1mg
$79.00
In stock
5mg
$309.00
In stock
10mg
$465.00
In stock

Tel:(909) 407-4943 Email: sales@glpbio.com

Customer Reviews

Based on customer reviews.

  • GlpBio Citations

    GlpBio Citations
  • Bioactive Compounds Premium Provider

    Bioactive Compounds Premium Provider

Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

View current batch:

Background

1H-1-ethyl Candesartan Cilexetil, which is a process-related impurity commonly found in the bulk synthesis of candesartan cilexetil, is a potent, long-acting, and selective angiotensin II type 1 receptor (AT1) antagonist.

Angiotensin II is a peptide that is mainly generated by the angiotensin converting enzyme and chymase, which plays a vital role in regulating blood pressure and sodium homeostasis via specific receptors including AT1[1]. AT1, localized in the kidney, heart, brain, adrenal gland, adipocytes, vascular smooth muscle cells, platelets, and placenta, is a major component of the renin-angiotensin system. Furthermore, AT1 mediates the classical biological actions of angiotensin II. Also, AT1 has seven helical transmembrane domains, which is the characteristic of the superfamily of G-protein-coupled receptors. Carboxyl-terminal region structure of AT1 plays important roles in receptor internalization, desensitization and phosphorylation [2].

In vitro: Up to now, in vitro study of 1H-1-ethyl candesartan cilexetil is still in the development stage.

In vivo: Up to now, in vivo study of 1H-1-ethyl candesartan cilexetil is still in the development stage.

References:
[1].  Otsuka, M. Reduction of bleomycin induced lung fibrosis by candesartan cilexetil, an angiotensin II type 1 receptor antagonist. Thorax. 2004; 59(1): 31-38.
[2].  GUO, D., SUN, Y., HAMET, P., & INAGAMI, T. The angiotensin II type 1 receptor and receptor-associated proteins. Cell Research. 2001; 11(3): 165-180.

Chemical Properties

Cas No. 914613-35-7 SDF
Chemical Name 2-ethoxy-1-[[2'-(1-ethyl-1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid, 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester
Canonical SMILES O=C(OC(C)OC(C1=C(N(CC2=CC=C(C3=C(C4=NN=NN4CC)C=CC=C3)C=C2)C(OCC)=N5)C5=CC=C1)=O)OC6CCCCC6
Formula C35H38N6O6 M.Wt 638.7
Solubility ≤30mg/ml in DMSO;30mg/ml in dimethyl formamide Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 1.5657 mL 7.8284 mL 15.6568 mL
5 mM 0.3131 mL 1.5657 mL 3.1314 mL
10 mM 0.1566 mL 0.7828 mL 1.5657 mL
  • Molarity Calculator

  • Dilution Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
**When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / CoA (available online).

Calculate

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Reviews

Review for 1H-1-ethyl Candesartan Cilexetil

Average Rating: 5 ★★★★★ (Based on Reviews and 39 reference(s) in Google Scholar.)

5 Star
100%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%
Review for 1H-1-ethyl Candesartan Cilexetil

GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.

Required fields are marked with *

You may receive emails regarding this submission. Any emails will include the ability to opt-out of future communications.