Home>>Lipids>> Sphingolipids>>2-Acetyl-5-tetrahydroxybutyl Imidazole

2-Acetyl-5-tetrahydroxybutyl Imidazole (Synonyms: 2-Acetyl-4-tetrahydroxybutyl Imidazole, 2-ATHBI, THI)

Catalog No.GC42112

Sphingosine-1-phosphate (S1P) lyase catalyzes the irreversible decomposition of S1P to hexadecanaldehyde and phosphoethanolamine.

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2-Acetyl-5-tetrahydroxybutyl Imidazole Chemical Structure

Cas No.: 94944-70-4

Size Price Stock Qty
500μg
$88.00
In stock
1mg
$167.00
In stock
5mg
$699.00
In stock
10mg
$1,224.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Sphingosine-1-phosphate (S1P) lyase catalyzes the irreversible decomposition of S1P to hexadecanaldehyde and phosphoethanolamine. 2-Acetyl-5-tetrahydroxybutyl imidazole (THI) is an inhibitor of S1P lyase. Because S1P lyase is primarily expressed in lymphatic tissue, treatment of mice with THI (50 µg/ml in drinking water) increases lymphoid tissue S1P concentrations 100-fold, reducing lymphocyte egress from thymus and peripheral lymphoid organs. The resulting lymphopenia is reversible following cessation of THI treatment. Reducing S1P lyase activity results in therapeutic levels of immunosuppression without the non-lymphoid lesions that result from synthetic S1P receptor agonists.

Chemical Properties

Cas No. 94944-70-4 SDF
Synonyms 2-Acetyl-4-tetrahydroxybutyl Imidazole, 2-ATHBI, THI
Canonical SMILES CC(=O)c1ncc([C@@H](O)[C@H](O)C(O)CO)[nH]1
Formula C9H14N2O5 M.Wt 230.2
Solubility DMSO: 2 mg/ml,PBS (pH 7.2): 0.15 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 4.344 mL 21.7202 mL 43.4405 mL
5 mM 0.8688 mL 4.344 mL 8.6881 mL
10 mM 0.4344 mL 2.172 mL 4.344 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 6 reference(s) in Google Scholar.)

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