20(S)-Hydroxycholesterol (Synonyms: 20α-hydroxy Cholesterol) |
| Catalog No.GC15422 |
An allosteric activator of the oncoprotein smoothened (Smo)
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Cas No.: 516-72-3
Sample solution is provided at 25 µL, 10mM.
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20(S)-hydroxyCholesterol (20α-Hydroxycholesterol) is an allosteric activator of the oncoprotein smoothened (Smo) that activates the hedgehog (Hh) signaling pathway with an EC50 of 3 μM in a gene transcription reporter assay using NIH3T3 cells[1][2].
References:
[1]. Nachtergaele S, et al. Oxysterols are allosteric activators of the oncoprotein Smoothened. Nat Chem Biol. 2012 Jan 8;8(2):211-20.
[2]. Nedelcu D, et al, Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling. Nat Chem Biol. 2013 Sep;9(9):557-64.
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