3β-hydroxy-5-Cholestenoic Acid (Synonyms: 3β-hydroxy-5-CA, Cholesterol-26-carboxylic Acid) |
| Catalog No.GC18817 |
3β-hydroxy-5-Cholestenoic acid is an active metabolite of cholesterol formed when cholesterol is metabolized by the cytochrome P450 (CYP) isomer CYP27A1.
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Cas No.: 6561-58-6
Sample solution is provided at 25 µL, 10mM.
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3β-hydroxy-5-Cholestenoic acid is an active metabolite of cholesterol formed when cholesterol is metabolized by the cytochrome P450 (CYP) isomer CYP27A1. 3β-hydroxy-5-Cholestenoic acid is a modulator of γ-secretase that decreases amyloid β (1-42) peptide (Aβ42; EC50 = 250 nM) and increases Aβ38 levels with no effect on total Aβ in CHO2B7 cells. It decreases endogenous murine Aβ42 production by 60 and 75% in mouse postnatal neuron-glia cultures at concentrations of 3 and 10 μM, respectively.
Review for 3β-hydroxy-5-Cholestenoic Acid
Average Rating: 5 (Based on Reviews and 33 reference(s) in Google Scholar.)
Review for 3β-hydroxy-5-Cholestenoic Acid
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