5,8,11-Eicosatriynoic Acid (Synonyms: 5,8,11-ETI) |
| Catalog No.GC13319 |
nonselective inhibitor of lipoxygenases (12-LO)
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 13488-22-7
Sample solution is provided at 25 µL, 10mM.
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5,8,11-Eicosatriynoic Acid is a selective inhibitor of lipoxygenases with ID50 values of 24 μM and 340 μM for n-8 lipoxygenase and fatty acid cycle-oxygenase , respectively[1][2].
Fatty acid cycle-oxygenase and n-8 lipoxygenase catalyze the initial reactions which lead to the formation of three major arachidonic acid metabolites in human platelets. In several tissues, these two enzymes act concomitantly on arachidonic acid [1].
5,8,11-Eicosatriynoic Acid (5,8,11-ET) is a selective inhibitor of lipoxygenases with ID50 values of 24 μM and 340 μM for n-8 lipoxygenase and fatty acid cycle-oxygenase, respectively. 5,8,11-Eicosatriynoic acid was useful for studies on physiological and pathophysiological roles of 12 L-hydroxy-5,8,10,14-eicosatetraenoic acid formation in various tissues [1]. In mouse mastocytoma cells, 5,8,11-Eicosatriynoic Acid inhibited A23187 and L-cysteine induced leukotriene C (LTC4) biosynthesis with ID50 value of 5 μM [2].
References:
[1]. Hammarstrm S. Selective inhibition of platelet n-8 lipoxygenase by 5,8,11-eicosatriynoic acid. Biochim Biophys Acta. 1977 Jun 22;487(3):517-9.
[2]. Orning L, Hammarstrm S. Inhibition of leukotriene C and leukotriene D biosynthesis. J Biol Chem. 1980 Sep 10;255(17):8023-6.
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