Home>>Lipids>> P450>>6β-hydroxy Dexamethasone

6β-hydroxy Dexamethasone (Synonyms: 6-hydroxyDEX, 6β-hydroxydexamethasone, 6OH-DEX)

Catalog No.GC18335

6β-hydroxy Dexamethasone is a metabolite of dexamethasone that is more hydrophilic than the parent compound.

Products are for research use only. Not for human use. We do not sell to patients.

6β-hydroxy Dexamethasone Chemical Structure

Cas No.: 55879-47-5

Size Price Stock Qty
500μg
$308.00
In stock
1mg
$584.00
In stock

Tel:(909) 407-4943 Email: sales@glpbio.com

Customer Reviews

Based on customer reviews.

  • GlpBio Citations

    GlpBio Citations
  • Bioactive Compounds Premium Provider

    Bioactive Compounds Premium Provider

Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

View current batch:

Background

6β-hydroxy Dexamethasone is a metabolite of dexamethasone that is more hydrophilic than the parent compound. Dexamethasone is metabolized by CYP3A4; therefore, quantification of the dexamethasone metabolites, 6α- and 6β-hydroxy dexamethasone, can be used to determine CYP3A4 enzyme activity in humans., The formation of 6-hydroxy dexamethasone metabolites is species-specific, with hamsters producing the highest amount. In rats, dexamethasone hydroxylation is sex-specific, with male rats producing metabolites in similar ratios to humans and female rats producing fewer hydroxylated metabolites than male rats.

References:
[1].Minagawa, K., Kasuya, Y., Baba, S., et al. Identification and quantification of 6 beta-hydroxydexamethasone as a major urinary metabolite of dexamethasone in man Steroids 47(2-3), 175-188 (1986).
[2].Gentile, D.M., Tomlinson, E.S., Maggs, J.L., et al. Dexamethasone metabolism by human liver in vitro. Metabolite identification and inhibition of 6-hydroxylation J. Pharmacol. Exp. Ther. 277(1), 105-112 (1996).
[3]. Zurbonsen, K., Bressolle, F., Solassol, I., et al. Simultaneous determination of dexamethasone and 6β-hydroxydexamethasone in urine using solid-phase extraction and liquid chromatography: Applications to in vivo measurement of cytochrome P450 3A4 activity J. Chomatogr. B Analyt. Technol. Biomed. Life Sci. 804(2), 421-429 (2004).
[4].Tomlinson, E.S., Maggs, J.L., Park, B.K., et al. Dexamethasone Metabolism in vitro: Species differences J. Steroid Biochem. Mol. Biol. 62(4), 345-352 (1997).

Chemical Properties

Cas No. 55879-47-5 SDF
Synonyms 6-hydroxyDEX, 6β-hydroxydexamethasone, 6OH-DEX
Chemical Name 9-fluoro-6β,11β,17,21-tetrahydroxy-16α-methyl-pregna-1,4-diene-3,20-dione
Canonical SMILES O=C1C=C[C@@]2(C)C([C@H](O)C[C@]3([H])[C@]2(F)[C@@H](O)C[C@@]4(C)[C@@]3([H])C[C@@H](C)[C@]4(O)C(CO)=O)=C1
Formula C22H29FO6 M.Wt 408.5
Solubility Methanol: slightly soluble Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.448 mL 12.2399 mL 24.4798 mL
5 mM 0.4896 mL 2.448 mL 4.896 mL
10 mM 0.2448 mL 1.224 mL 2.448 mL
  • Molarity Calculator

  • Dilution Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
**When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / CoA (available online).

Calculate

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Reviews

Review for 6β-hydroxy Dexamethasone

Average Rating: 5 ★★★★★ (Based on Reviews and 5 reference(s) in Google Scholar.)

5 Star
100%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%
Review for 6β-hydroxy Dexamethasone

GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.

Required fields are marked with *

You may receive emails regarding this submission. Any emails will include the ability to opt-out of future communications.