β-CGRP (human) (trifluoroacetate salt) (Synonyms: α-Calcitonin Gene-Related Peptide (human), Calcitonin Gene Related Peptide-1 (human), CGRP-1 (human)) |
| Catalog No.GC45227 |
β-Calcitonin gene-related peptide (β-CGRP) is a neuropeptide with roles in vasodilation, cardiovascular regulation, and inflammation.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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β-Calcitonin gene-related peptide (β-CGRP) is a neuropeptide with roles in vasodilation, cardiovascular regulation, and inflammation. It belongs to the calcitonin family of peptides, which also includes α-CGRP , amylin , calcitonin , and adrenomedullin. β-CGRP binds selectively to a heteromeric complex of calcitonin receptor-like receptor (CRLR) and receptor activity-modifying protein 1 (RAMP1; IC50 = 0.01 nM) over a complex of CLCR and RAMP2 (IC50 = 300 nM). It binds to rat brain and spleen membrane preparations (IC50s = 1.1 and 1 nM, respectively) and relaxes human cerebral and middle meningeal arterial segments precontracted with prostaglandin F2α . In vivo, β-CGRP induces a 50% increase in diameter of arterioles precontracted with human endothelin-1 in hamster cheek pouch at a concentration of 15.8 pM.
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