β-Endorphin (1-26) (human) (trifluoroacetate salt) |
| Catalog No.GC45233 |
β-endorphin (1-26) is a neuropeptide found in rat hippocampus, brain stem, and pituitary.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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β-endorphin (1-26) is a neuropeptide found in rat hippocampus, brain stem, and pituitary. It is also present in the human hypothalamus, where it comprises approximately 13.1% of total β-endorphin. β-endorphin (1-26) is an opioid receptor agonist that inhibits potassium-induced norepinephrine (NE) release in rat cortical slices (IC50 = 2.5 nM). It reverses inhibition of potassium-induced NE release from rat cortical slices induced by the opioid antagonists naloxone , CTOP, norbinaltorphimine (nor-BNI), and naltrindole . In vivo, β-endorphin (1-26) (10 μg, i.c.v.) induces transient bradycardia in anesthetized rats. Intracerebroventricular administration of β-endorphin (1-26) increases the latency to tail withdrawal in response to thermal stimulation in mice with a median antinociceptive dose (AD50) of 1.57 μg per animal.
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