Amylin (rat, mouse) (trifluoroacetate salt) (Synonyms: IAPP (rat, mouse), Islet Amyloid Polypeptide (rat, mouse)) |
| Catalog No.GC42797 |
Amylin is a 37-residue peptide hormone secreted by pancreatic β-cells that reduces food intake, modifies glycogen synthesis, slows gastric emptying, and increases satiety.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Amylin is a 37-residue peptide hormone secreted by pancreatic β-cells that reduces food intake, modifies glycogen synthesis, slows gastric emptying, and increases satiety. It binds to heteromeric complexes of human calcitonin receptor 2 (CTR2) with receptor activity-modifying protein (RAMP) 1 or 3 (IC50s = 7.86 and 6.35 nM, respectively). It also binds to mouse α-thyroid-stimulating hormone thyrotroph (α-TSH) cells (IC50 = 10.5 nM) and rat nucleus accumbens membrane preparations (Ki = 0.024 nM). In vitro, amylin (100 nM) inhibits insulin-induced, but not basal, glycogen synthesis in hepatocytes isolated from fasted rats. It also inhibits insulin-induced glycogen synthesis ex vivo in isolated soleus muscle from fasted rats. In vivo, amylin delays gastric emptying in rats (ED50 = 69 pmol) and decreases food intake in fasted mice (ED50 = 110 μg/kg). Unlike human amylin , rat amylin does not form fibrils and is not cytotoxic.
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