Mastoparan |
Catalog No.GC12692 |
Gi and Go activator
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 72093-21-1
Sample solution is provided at 25 µL, 10mM.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Mastoparan, a tetradecapeptide which is a component of wasp venom, stimulates release of prolactin from cultured rat anterior pituitary cells.
Mastoparan has an amphiphilic nature and is reported to exert a variety of pharmacological and biochemical effects. Mastoparan induces exocytosis of hormones from anterior pituitary cells. Mastoparan stimulation of prolactin secretion is dose-dependent, time-dependent, reversible and required the presence of calcium. Mastoparan causes translocation of protein kinase C activity from a soluble to a membrane-attached form. Mastoparan is able to increase the intracellular Ca2+ concentration in Fura-2-loaded individual lactotrophs. Mastoparan is also able to interact with GTP-bindmg proteins. Thus, Mastoparan has been shown to facilitate exchange of nucleotides and to stimulate GTPase activity on G-proteins. It has therefore been proposed that the cellular effects of Mastoparan are due to an ability to mimic G-protein-linked agonist-liganded receptors[1].
References:
[1]. Mau SE, et al. Mastoparan, a wasp venom peptide, stimulates release of prolactin from cultured rat anterior pituitary cells. J Endocrinol. 1994 Jul;142(1):9-18.
Cas No. | 72093-21-1 | SDF | |
Chemical Name | (S,Z)-2-((Z)-((2S,3S)-2-amino-1-hydroxy-3-methylpentylidene)amino)-N'1-((4S,5Z,7S,8Z,10S,11Z,13S,14Z,16S,17Z,19S,20Z,22S,23Z,25S,26Z,28S,29Z,31S,32Z,34S,35Z,37S)-10,13,34-tris(4-aminobutyl)-7-((S)-sec-butyl)-6,9,12,15,18,21,24,27,30,33,36-undecahydroxy-4- | ||
Canonical SMILES | CC[C@]([C@@](N)([H])/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](C(O)=N)([H])CC(C)C)([H])[C@@](CC)([H])C)([H])CCCCN)([ | ||
Formula | C70H131N19O15 | M.Wt | 1479 |
Solubility | Soluble to 2.60 mg/ml in sterile water | Storage | Desiccate at -20°C |
General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. |
Prepare stock solution | |||
1 mg | 5 mg | 10 mg | |
1 mM | 0.6761 mL | 3.3807 mL | 6.7613 mL |
5 mM | 0.1352 mL | 0.6761 mL | 1.3523 mL |
10 mM | 0.0676 mL | 0.3381 mL | 0.6761 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Average Rating: 5
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