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SCH 202676 hydrobromide

Catalog No.GC15816

inhibitor of both agonist and antagonist binding to diverse GPCRs

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SCH 202676 hydrobromide Chemical Structure

Cas No.: 70375-43-8,265980-25-4

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5mg
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25mg
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50mg
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

SCH 202676 is a reversible inhibitor of both agonist and antagonist binding to diverse G protein-coupled receptors (GPCRs).1 It blocks the binding of radiolabeled ligands to human opioid, adrenergic, muscarinic, dopaminergic, adenosine, and purinergic receptors.[1],[2],[3] It displays IC50 values of 0.1 to 1.8 µM for modulating ligand binding.1,2 SCH 202676 may modulate GPCRs via thiol modification.[4]

References
[1]. Fawzi, A.B., Macdonald, D., Benbow, L.L., et al. SCH-202676: An allosteric modulator of both agonist and antagonist binding to G protein-coupled receptors. Molecular Pharmacology 59(1), 30-37 (2001).
[2]. Gao, Z.G., Kim, S.K., Ijzerman, A.P., et al. Allosteric modulation of the adenosine family of receptors. Mini Rev.Med.Chem. 5(6), 545-553 (2005).
[3]. Lanzafame, A., and Christopoulos, A. Investigation of the interaction of a putative allosteric modulator, N-(2,3-diphenyl-1,2,4-thiadiazole-5-(2H)-ylidene) methanamine hydrobromide (SCH-202676), with M1 muscarinic acetylcholine receptors. Journal of Pharmacology and Experimental Therapeutics 308(3), 830-837 (2004).
[4]. Lewandowicz, A.M., Vepsäläinen, J., and Laitinen, J.T. The 'allosteric modulator' SCH-202676 disrupts G protein-coupled receptor function via sulphydryl-sensitive mechanisms. British Journal of Pharmacology 147(4), 422-429 (2006).

Chemical Properties

Cas No. 70375-43-8,265980-25-4 SDF
Chemical Name (E)-N-(2,3-diphenyl-1,2,4-thiadiazol-5(2H)-ylidene)methanamine hydrobromide
Canonical SMILES C/N=C(S1)\N=C(N1C2=CC=CC=C2)C3=CC=CC=C3.Br
Formula C15H13N3S.HBr M.Wt 348.26
Solubility 10mg/mL in DMSO, 5mg/mL in DMF Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.8714 mL 14.3571 mL 28.7142 mL
5 mM 0.5743 mL 2.8714 mL 5.7428 mL
10 mM 0.2871 mL 1.4357 mL 2.8714 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 11 reference(s) in Google Scholar.)

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