CAY10626 |
| Catalog No.GC18884 |
CAY10626 is a PI3Kα/mTOR dual kinase inhibitor. CAY10626 has IC50s of 0.9, 0.6 nM for PI3Kα and mTOR, respectively. CAY10626 can be used for the research of cancer.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1202884-94-3
Sample solution is provided at 25 µL, 10mM.
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Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of the 3' hydroxyl position of PIs to produce PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3, important second messengers that modulate the activity of downstream targets Akt and mTOR. Aberrant PI3K/Akt is associated with many human cancers. CAY10626 is a potent, dual PI3Kα/mTOR inhibitor with IC50 values of 0.9 and 0.6 nM for the two respective kinases. In a tumor cell growth inhibition assay, CAY10626 demonstrates IC50 values of 50 mg/k to MD361 xenograft mice, phosphorylation of the downstream targets of PI3Kα and mTOR (Akt T308, Akt S473, and S6K) was suppressed, and significant tumor regression was observed.
Review for CAY10626
Average Rating: 5 (Based on Reviews and 34 reference(s) in Google Scholar.)
Review for CAY10626
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