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CB-6644

Catalog No.GC34317

CB-6644 is a selective inhibitor of RUVBL1/2 complex with anti-cancer activity. CB-6644 blocks the ATPase activity of RUVBL1/2 with an IC50 of 15 nM.

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CB-6644 Chemical Structure

Cas No.: 2316817-88-4

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1mg
$315.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

CB-6644 is a selective inhibitor of RUVBL1/2 complex with anti-cancer activity. CB-6644 blocks the ATPase activity of RUVBL1/2 with an IC50 of 15 nM[1].

CB-6644 (20 µM) interacts with the RUVBL1/2 complex in Ramos cells[1]. CB-6644 (0.4 µM, 80 hours) dramatically inhibits HCT116 cells growth rate and robustly induces apoptosis. Z-VAD-FMK alone does not influence the growth or viability of the cells. However, blockade of caspase activity by Z-VAD-FMK results in a partial recovery of the growth of cells treated with CB-6644[1].|| Cell Viability Assay[1]||Cell Line:|HCT116 cells|Concentration:|0.4 µM|Incubation Time:|80 hours|Result:|Inhibited dramatically cell growth rate.

CB-6644 (150 mg/kg, oral administration, 10 days of treatment for SCID-beige mice bearing Ramos xenograft models, 30 days of treatment for SCID-beige mice bearing RPMI8226 xenograft models) has antitumor activity in xenograft tumor models with tumor growth inhibitions (TGIs) of 68 and 81%, respectively in Ramos xenograft models and RPMI8226 xenograft models[1].|| Animal Model:|SCID-beige mice bearing human tumor xenografts derived from either Burkitt's lymphoma (Ramos) or multiple myeloma (RPMI8226) cell lines[1]|Dosage:|150 mg/kg|Administration:|Oral gavage once (qd) or twice (BID) daily, 10 days of treatment for Ramos, 30 days of treatment for RPMI8226|Result:|There was no significant bodyweight loss in mice. TGI of 68 and 81% in Ramos and RPMI8226, respectively.

[1]. Assimon VA, et al. CB-6644 Is a Selective Inhibitor of the RUVBL1/2 Complex with Anticancer Activity. ACS Chem Biol. 2019 Feb 15;14(2):236-244.

Chemical Properties

Cas No. 2316817-88-4 SDF
Canonical SMILES COCC1=C(NC(CC(C)(C)CNC(C2=C(OCC)C=C(F)C(Cl)=C2)=O)=O)C(N(N1CCC3)C4=C3C=CC=C4)=O
Formula C29H34ClFN4O5 M.Wt 573.06
Solubility DMSO: 100 mg/mL (174.50 mM) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 1.745 mL 8.7251 mL 17.4502 mL
5 mM 0.349 mL 1.745 mL 3.49 mL
10 mM 0.1745 mL 0.8725 mL 1.745 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 33 reference(s) in Google Scholar.)

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