| Compound 48/80 (hydrochloride) Catalog No.GC43305 |
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
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Purity ≥ 95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
| Cas No. | 848035-21-2 | SDF | Download SDF |
| Synonyms | N/A | ||
| Chemical Name | 4-methoxy-3,5-bis[[2-methoxy-5-[2-(methylamino)ethyl]phenyl]methyl]-N-methyl-benzeneethanamine, trihydrochloride | ||
| Canonical SMILES | COC1=CC=C(CCNC)C=C1CC2=CC(CCNC)=CC(CC3=C(OC)C=CC(CCNC)=C3)=C2OC.Cl.Cl.Cl | ||
| Formula | C32H45N3O3 • 3HCl | M.Wt | 629.1 |
| Solubility | 100mM in water | Storage | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. | ||
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
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Compound 48/80 is a condensation product of N-methyl-p-methoxyphenethylamine with formaldehyde that causes histamine degranulation from mast cells.[1] Compound 48/80 also inhibits human platelet aggregation through suppression of calmodulin (CaM) (IC50 = 0.41 μg/ml for CaM-dependent Ca2+-transporter ATPase activity) and phospholipase C (IC50s = 2.1 and 5.0 μg/ml for cytosolic and particulate phosphatidylinositol-specific activities, respectively).[2],[3]
Reference:
[1]. Rothschild, A.M. Mechanisms of histamine release by compound 48/80. Br. J. Pharmac. 38(1), 253-262 (1970).
[2]. Adamczyk-Engelmann, P., and Gietzen, K. Induction of histamine release and calmodulin antagonism are two distinct properties of compound 48/80. Cell Calcium 10(2), 93-99 (1989).
[3]. Bronner, C., Charles, W., Didier, M., et al. Compound 48/80 is a potent inhibitor of phospholipase C and a dual modulator of phospholipase A2 from human platelet. Biochim Biophys. Acta. 920(3), 301-305 (1987).