CTA 056 |
| Catalog No.GC50076 |
ITK inhibitor
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1265822-30-7
Sample solution is provided at 25 µL, 10mM.
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Interleukin-2-inducible T-cell kinase (ITK) inhibitor (IC50 values are 0.1, 0.4 and 5 μM for ITK, BTK and ETK, respectively). Inhibits growth of cancer cells expressing ITK, including MOLT-4 and Jurkat cells in vitro. Induces apoptosis in Jurkat cells. Inhibits MOLT-4 xenograft tumor growth in mice.
Guo et al (2012) Molecular characteristics of CTA056, a novel interleukin-2-inducible T-cell kinase inhibitor that selectively targets malignant T cells and modulates oncomirs. Mol.Pharmacol. 82 938 PMID:22899868
Average Rating: 5 (Based on Reviews and 15 reference(s) in Google Scholar.)
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