D-erythro-MAPP (Synonyms: (1S,2RDerythro2Nmyristoylamino)1phenyl1propanol) |
| Catalog No.GC40296 |
D-erythro-MAPP is a derivative of ceramide and an inhibitor of alkaline ceramidase (Ki = 2-13 μM; IC50 = 1-5 μM).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 143492-38-0
Sample solution is provided at 25 µL, 10mM.
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D-erythro-MAPP is a derivative of ceramide and an inhibitor of alkaline ceramidase (Ki = 2-13 µM; IC50 = 1-5 µM). It is selective for alkaline ceramidase over acid ceramidase (IC50 = >500 µM) as well as the serine/threonine protein phosphatase CAPP at concentrations up to 10 µM. D-erythro-MAPP increases intracellular ceramide levels, induces cell cycle arrest at the G0/G1 phase, and inhibits growth of HL-60 promyelocytic leukemia cells in a time- and concentration-dependent manner.
Average Rating: 5 (Based on Reviews and 32 reference(s) in Google Scholar.)
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