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Desmopressin

Catalog No.GC12303

A vasopressin receptor agonist

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Desmopressin Chemical Structure

Cas No.: 16679-58-6

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5mg
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10mg
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50mg
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Sample solution is provided at 25 µL, 10mM.

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Background

Desmopressin (dDAVP) is a synthetic peptide analog of natural pituitary hormone 8-arginine vasopressin (ADH) with hemostatic and anti-diuretic properties [1].
Desmopressin reduced the formation of lung nodules in F3II tumor cell injected BALB/c mice. In vitro, desmopressin blocked the F3II cell colony formation. Desmopressin could inhibit metastasis formation on V2 vasopressin receptors in both endothelial and cancer cells [1].
Desmopressin has been proved to increase the release of platelet adhesion promoting factors which is most likely von Willebrand factor (VWF), from endothelial cells (ECs). However, desmopressin had no direct effect on platelets [2].
The administration of desmopressin agglomerates in rats significantly reduced the urine production [3]. Apart from these, rats treated by desmopressin had demonstrated a stronger Pimonidazole staining in the outer and inner medulla compared to control. Desmopressin-treated rats revealed nuclear accumulation in the papilla, which was confirmed by HIF-1α immunostaining. Desmopressin-treated animals had shown a significant increase of HIF-target genes in the group of Desmopressin-regulated gene products including insulin-like growth factor binding proteins 1 and 3, fibronectin, hexokinase 2, angiopoietin 2, cathepsin D and cyclooxygenase 2. Desmopressin had been shown to cause the renal urine concentrating mechanism, leading to an upregulation of hypoxia-inducible gene expression and renal medullary hypoxia [4].
References:
1.Garona J1, Pifano M1, Scursoni AM2, Gomez DE1, Alonso DF3, Ripoll GV1.Insight into the effect of the vasopressin analog desmopressin on lung colonization by mammary carcinoma cells in BALB/c mice. Anticancer Res. 2014 Sep;34(9):4761-5.
2.Calmer S1, Ferkau A, Larmann J, Johanning K, Czaja E, Hagl C, Echtermeyer F, Goudeva L, Heuft HG, Theilmeier G. Desmopressin (DDAVP) improves recruitment of activated platelets to collagen but simultaneously increases platelet endothelial interactions in vitro. Platelets. 2014;25(1):8-15.
3.Balducci AG1, Ferraro L, Bortolotti F, Nastruzzi C, Colombo P, Sonvico F, Russo P, Colombo G. Antidiuretic effect of desmopressin chimera agglomerates by nasal administration in rats. Int J Pharm. 2013 Jan 20;440(2):154-60.
4.Dietrich A1, Mathia S, Kaminski H, Mutig K, Rosenberger C, Mrowka R, Bachmann S, Paliege A. Chronic activation of vasopressin V2 receptor signalling lowers renal medullary oxygen levels in rats. Acta Physiol (Oxf). 2013 Apr;207(4):721-31.

Chemical Properties

Cas No. 16679-58-6 SDF
Chemical Name 1-(7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carbonyl)-N-(1-((2-amino-2-oxoethyl)amino)-5-((diaminomethylene)amino)-1-oxopentan-2-yl)pyrrolidine-2-ca
Canonical SMILES O=C(C1CSSCCC(NC(CC2=CC=C(O)C=C2)C(NC(CC3=CC=CC=C3)C(NC(CCC(N)=O)C(NC(CC(N)=O)C(N1)=O)=O)=O)=O)=O)N4C(C(NC(C(NCC(N)=O)=O)CCC/N=C(N)\N)=O)CCC4
Formula C46H64N14O12S2 M.Wt 1069.22
Solubility DMF: 1 mg/ml,DMSO: 5 mg/ml,PBS (pH 7.2): 2 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 0.9353 mL 4.6763 mL 9.3526 mL
5 mM 0.1871 mL 0.9353 mL 1.8705 mL
10 mM 0.0935 mL 0.4676 mL 0.9353 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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