F 16915 |
| Catalog No.GC34039 |
F 16915, a Docosahexaenoic Acid derivative, is a potent pro-drug of DHA.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 92510-91-3
Sample solution is provided at 25 µL, 10mM.
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F 16915 is a docosahexaenoic acid derivative which can prevent heart failure-induced atrial fibrillation.
F 16915 is a docosahexaenoic acid derivative which can prevent heart failure-induced atrial fibrillation. Time-dependent changes in blood concentrations of total docosahexaenoic acid (DHA) and nicotinyl alcohol are followed after a single oral administration of F 16915 (300 mg/kg) to male rats. Treatment with F 16915 has no significant effect on body weight: 27.7±2.9 kg and 28.1±1.0 kg before surgery versus 29.2±3.4 kg and 28.8±1.7 kg after in the 1 and 5 g/day groups, respectively. F 16915 administered at 5 g/day for 4 weeks significantly reduces the mean duration of Atrial fibrillation (AF) induced by burst pacing but has no significant effect at 1 g/day. The duration of AF is significantly reduced from 989±111 s in the placebo group to 79±59 s in the presence of F 16915 at 5 g/day. Treatment of 2 months with 100 mg/kg F 16915 also significantly reduces the infarct size[1].
[1]. Le Grand B, et al. F 16915 prevents heart failure-induced atrial fibrillation: a promising new drug as upstream therapy. Naunyn Schmiedebergs Arch Pharmacol. 2014 Jul;387(7):667-77.
Average Rating: 5 (Based on Reviews and 15 reference(s) in Google Scholar.)
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