A-770041 |
| Catalog No.GC35213 |
A-770041 is a selective and orally active Src-family Lck inhibitor.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 869748-10-7
Sample solution is provided at 25 µL, 10mM.
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A-770041 is selective and orally active Src-family Lck inhibitor; A-770041 is a 147 nM inhibitor of Lck (1 mM ATP) and is 300-fold selective against Fyn, the other Src family kinase involved in T-cell signaling.IC50 value: 147 nMTarget: Lck
[1]. Stachlewitz RF, et al.A-770041, a novel and selective small-molecule inhibitor of Lck, prevents heart allograft rejection.J Pharmacol Exp Ther. 2005 Oct;315(1):36-41. [2]. Andrew Burchat, et al. Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection Bioorganic & Medicinal Chemistry Letters Volume 16, Issue 1, 1 January 2006, Pages 118-122
Average Rating: 5 (Based on Reviews and 3 reference(s) in Google Scholar.)
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