Adenosine deaminase |
| Catalog No.GC35250 |
Involved in metabolism of purines
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 9026-93-1
Sample solution is provided at 25 µL, 10mM.
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Adenosine deaminase is an enzyme that catalyzes the irreversible deamination of adenosine and 2'-deoxyadenosine to inosine and 2'-deoxyinosine, respectively.
Adenosine deaminase (ADA; EC 3.5.4.4) catalyzes the irreversible deamination of adenosine and 2′-deoxyadenosine to inosine and 2′-deoxyinosine, respectively. Adenosine deaminase is implicated in purine metabolism and distributed in most mammalian tissues. Genetic Adenosine deaminase deficiency results in lymphopenia and severe combined immunodeficiency disease by decreasing the differentiation and maturation of lymphoid cells[1]. Adenosine deaminase is a signaling molecule related to the activation of T lympho-cytes, making it a useful inflammation marker, especially for menin-gitis and tuberculous pleuritis[2].
[1]. Tian X, et al. Probing inhibition mechanisms of adenosine deaminase by using molecular dynamics simulations. PLoS One. 2018 Nov 16;13(11):e0207234.
[2]. Silva Dalsasso Joaquim L, et al. Analytical validation of an in-house method for adenosine deaminase determination. J Clin Lab Anal. 2018 Nov 29:e22823.
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