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Prednisolone farnesylate

Catalog No.GC36959

Prednisolone farnesylate (PNF21) is a new transdermal corticosteroid with anti-inflammatory activity.

Products are for research use only. Not for human use. We do not sell to patients.

Prednisolone farnesylate Chemical Structure

Cas No.: 118244-44-3

Size Price Stock Qty
1mg
$371.00
In stock
5mg
$742.00
In stock
10mg
$1,261.00
In stock
20mg
$2,225.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Prednisolone farnesylate (PNF21) is a new transdermal corticosteroid with anti-inflammatory activity.

Prednisolone farnesylate is a synthetic glucocorticoid, which is a compound of Prednisolone and its ester Farnesylate and is known to suppress local swelling of the adjuvant-induced arthritis[1].

[1]. Kato N, et al. Treatment of the chronic inflammation in peripheral target tissue improves the crushed nerve recovery in the rat: histopathological assessment of the nerve recovery. J Neurol Sci. 2002 Oct 15;202(1-2):69-74.

Chemical Properties

Cas No. 118244-44-3 SDF
Canonical SMILES C[C@@]12[C@](CC[C@]2(O)C(COC(/C=C(C)/CC/C=C(C)/CC/C=C(C)/C)=O)=O)([H])[C@@]3([H])[C@]([C@@]4(C(CC3)=CC(C=C4)=O)C)([H])[C@@H](O)C1
Formula C36H50O6 M.Wt 578.78
Solubility Soluble in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 1.7278 mL 8.6389 mL 17.2777 mL
5 mM 0.3456 mL 1.7278 mL 3.4555 mL
10 mM 0.1728 mL 0.8639 mL 1.7278 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Reviews

Review for Prednisolone farnesylate

Average Rating: 5 ★★★★★ (Based on Reviews and 39 reference(s) in Google Scholar.)

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