GDC-0077 (RG6114) (Synonyms: GDC-0077; RG6114) |
| Catalog No.GC32710 |
GDC-0077 (RG6114) is a potent, orally available, and selective PI3Kα inhibitor (IC50=0.038 nM). GDC-0077 (RG6114) exerts its activity by binding to the ATP binding site of PI3K, thereby inhibiting the phosphorylation of PIP2 to PIP3. GDC-0077 (RG6114) is more selective for mutant versus wild-type PI3Kα.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2060571-02-8
Sample solution is provided at 25 µL, 10mM.
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GDC-0077 is an orally available PI3K inhibitor with potential antineoplastic activity. GDC-0077 is extracted from patent WO 2017001645 A1, formula I.
[1]. WO 2017001645 A1
Average Rating: 5 (Based on Reviews and 39 reference(s) in Google Scholar.)
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