Home>>Signaling Pathways>> Proteases>> Endogenous Metabolite>>Glycoursodeoxycholic acid (Ursodeoxycholylglycine)
Glycoursodeoxycholic acid (Ursodeoxycholylglycine) Catalog No.GC33687

Size Price Stock Qty
10mM*1mLinDMSO
$49.00
In stock
10mg
$45.00
In stock
50mg
$71.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Chemical Properties

Cas No. 64480-66-6 SDF Download SDF
Synonyms N/A
Chemical Name N/A
Canonical SMILES O=C(O)CNC(CC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])[C@@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)=O
Formula C26H43NO5 M.Wt 449.62
Solubility Soluble in DMSO Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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Background

Glycoursodeoxycholic acid, a acyl glycine and a bile acid-glycine conjugate, is a metabolite of ursodeoxycholic acid.In Vitro: The antioxidant compound glycoursodeoxycholic acid (GUDCA) fully abrogates UCB-induced cytochrome c oxidase inhibition and significantly prevents oxidative stress, metabolic alterations, and cell demise[1].GUDCA has shown therapeutic efficacy in neurodegenerative models and diseases. Increased cytosolic SOD1 inclusions were observed in 4 DIV NSC-34/hSOD1(G93A) cells together with decreased mitochondria viability, caspase-9 activation, and apoptosis[2]. Glycoursodeoxycholic acid shows preventive and restorative effects against unconjugated bilirubin -induced blood-brain barrier disruption and damage to human brain microvascular endothelial cells[3].