Hellebrin (Synonyms: NSC 93134) |
| Catalog No.GC18701 |
Hellebrin is a cardiac glycoside that potently inhibits the Na+/K+-ATPase by binding to it and blocking its non-canonical function as a receptor for cardiac glycosides.
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Cas No.: 13289-18-4
Sample solution is provided at 25 µL, 10mM.
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Hellebrin is a cardiac glycoside that potently inhibits the Na+/K+-ATPase by binding to it and blocking its non-canonical function as a receptor for cardiac glycosides. Hellebrin has a higher affinity for the α1β1 subunit of the Na+/K+-ATPase than the α2β1 or α3β1 complexes, in contrast to other cardiac glycosides. This affinity for the α1β1 complex correlates with its cancer cell growth inhibition (GI50 = 6-58 nM in various human cancer cell lines). Hellebrin also induces caspase-dependent apoptosis in Jurkat T cells.
Review for Hellebrin
Average Rating: 5 (Based on Reviews and 38 reference(s) in Google Scholar.)
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