Homatropine Methylbromide (Synonyms: NSC 34399) |
Catalog No.GC17908 |
Muscarinic AChR antagonist
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 80-49-9
Sample solution is provided at 25 µL, 10mM.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Homatropine methylbromide (Homatropine methobromide) is muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively.
Homatropine methylbromide (Homatropine methobromide) (20 μM) alone produces a dose ratio of 259 in atrium from guinea-pigs. Homatropine methylbromide (Homatropine methobromide) (20 μM) produces a dose ratio of only 95.0 when combined with hexamethonium in atrium from guinea-pigs.
Pre-treatment with Homatropine methylbromide (Homatropine methobromide) (20 mg/kg) was comparable with atropine (10 mg/kg) in preventing lethality in this rat model of acute OC poisoning.
References:
[1]. Sim MK et al. Muscarinic receptors in the aortae of normo- and hypertensive rats: a binding study.Clin Exp Hypertens. 1993 Mar;15(2):409-21.
[2]. Bryant SM et al. Intramuscular ophthalmic homatropine vs. atropine to prevent lethality in rates with dichlorvos poisoning. J Med Toxicol. 2006 Dec;2(4):156-9.
[3]. Leung E et al. Modification by hexamethonium of the muscarinic receptors blocking activity of pancuronium and homatropine in isolated tissues of the guinea-pig.Eur J Pharmacol. 1982 May 7;80(1):11-7.
Cas No. | 80-49-9 | SDF | |
Synonyms | NSC 34399 | ||
Chemical Name | [(1R,5S)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octan-3-yl] 2-hydroxy-2-phenylacetate;bromide | ||
Canonical SMILES | C[N+]1(C2CCC1CC(C2)OC(=O)C(C3=CC=CC=C3)O)C.[Br-] | ||
Formula | C17H24NO3.Br | M.Wt | 370.28 |
Solubility | ≥ 17.95mg/mL in DMSO | Storage | Store at -20°C |
General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. |
Prepare stock solution | |||
1 mg | 5 mg | 10 mg | |
1 mM | 2.7007 mL | 13.5033 mL | 27.0066 mL |
5 mM | 0.5401 mL | 2.7007 mL | 5.4013 mL |
10 mM | 0.2701 mL | 1.3503 mL | 2.7007 mL |
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Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Average Rating: 5
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