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Homatropine Methylbromide (Synonyms: NSC 34399)

Catalog No.GC17908

Muscarinic AChR antagonist

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Homatropine Methylbromide Chemical Structure

Cas No.: 80-49-9

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10mM (in 1mL DMSO) Please Inquire Please Inquire
50mg
$46.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Homatropine methylbromide (Homatropine methobromide) is muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively.

Homatropine methylbromide (Homatropine methobromide) (20 μM) alone produces a dose ratio of 259 in atrium from guinea-pigs. Homatropine methylbromide (Homatropine methobromide) (20 μM) produces a dose ratio of only 95.0 when combined with hexamethonium in atrium from guinea-pigs.

Pre-treatment with Homatropine methylbromide (Homatropine methobromide) (20 mg/kg) was comparable with atropine (10 mg/kg) in preventing lethality in this rat model of acute OC poisoning.

References:
[1]. Sim MK et al. Muscarinic receptors in the aortae of normo- and hypertensive rats: a binding study.Clin Exp Hypertens. 1993 Mar;15(2):409-21.
[2]. Bryant SM et al. Intramuscular ophthalmic homatropine vs. atropine to prevent lethality in rates with dichlorvos poisoning. J Med Toxicol. 2006 Dec;2(4):156-9.
[3]. Leung E et al. Modification by hexamethonium of the muscarinic receptors blocking activity of pancuronium and homatropine in isolated tissues of the guinea-pig.Eur J Pharmacol. 1982 May 7;80(1):11-7.

Chemical Properties

Cas No. 80-49-9 SDF
Synonyms NSC 34399
Chemical Name [(1R,5S)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octan-3-yl] 2-hydroxy-2-phenylacetate;bromide
Canonical SMILES C[N+]1(C2CCC1CC(C2)OC(=O)C(C3=CC=CC=C3)O)C.[Br-]
Formula C17H24NO3.Br M.Wt 370.28
Solubility ≥ 17.95mg/mL in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.7007 mL 13.5033 mL 27.0066 mL
5 mM 0.5401 mL 2.7007 mL 5.4013 mL
10 mM 0.2701 mL 1.3503 mL 2.7007 mL
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