Indoxyl Sulfate (potassium salt) |
| Catalog No.GC43903 |
Indoxyl Sulfate (potassium salt) is an endogenous metabolite.
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Cas No.: 2642-37-7
Sample solution is provided at 25 µL, 10mM.
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Indoxyl Sulfate (IS), also known as 3-indoxylsulfate and 3-indoxylsulfuric acid, is a metabolite of dietary L-tryptophan that acts as a cardiotoxin and uremic toxin[1]. Indoxyl Sulfate is taken up by proximal tubular cells through organic anion transporters (OAT1, OAT3), and it induces reactive oxygen species (ROS) with impairment of cellular antioxidative system[2-3].
Indoxyl Sulfate (62.5-1000µM;24h) induces intestinal damage via inhibiting mitophagic flux in Caco2 cells[4]. Indoxyl Sulfate (1 mM;12 h) induces fibrotic responses of tubular epithelial cells, renal fibroblasts, and macrophages via mTORC1 signaling [5]. Indoxyl Sulfate (1 mM;24 h) induces monocyte chemoattractant protein-1 (MCP-1) expression and reactive oxygen species (ROS) production in the differentiated 3T3L-1 adipocyte[6].
After injection of Indoxyl Sulfate (100 mg/kg; i.p; 8 weeks), the intestinal macroscopical damage and permeability of mice increased, and the serum Indoxyl Sulfate level increased [4]. Indoxyl Sulfate (10-3 M, 60 min) augments ET-1-induced contraction in rat aortae [7]. Indoxyl Sulfate (200 mg/kg/day of Indoxyl Sulfate in water) downregulates renal expression of Nrf2 through activation of NF-κB, followed by downregulation of HO-1 and NQO1 and increased production of ROS[8]. Indoxyl Sulfate increased endothelin-1-induced contraction but had no effect on phenylephrine, thromboxane analog, or isotonic K+-induced renal arterial contractions[9].
References:
[1]. Lano G, Burtey S, et,al. Indoxyl Sulfate, a Uremic Endotheliotoxin. Toxins (Basel). 2020 Apr 5;12(4):229. doi: 10.3390/toxins12040229. PMID: 32260489; PMCID: PMC7232210.
[2]. Niwa T, Shimizu H. Indoxyl sulfate induces nephrovascular senescence. J Ren Nutr. 2012 Jan;22(1):102-6. doi: 10.1053/j.jrn.2011.10.032. PMID: 22200425.
[3]. Niwa T. Indoxyl sulfate is a nephro-vascular toxin. J Ren Nutr. 2010 Sep;20(5 Suppl):S2-6. doi: 10.1053/j.jrn.2010.05.002. PMID: 20797565.
[4]. Huang Y, Zhou J, et,al. Indoxyl sulfate induces intestinal barrier injury through IRF1-DRP1 axis-mediated mitophagy impairment. Theranostics. 2020 Jun 5;10(16):7384-7400. doi: 10.7150/thno.45455. PMID: 32641998; PMCID: PMC7330852.
[5]. Nakano T, Watanabe H, et,al.Indoxyl Sulfate Contributes to mTORC1-Induced Renal Fibrosis via The OAT/NADPH Oxidase/ROS Pathway. Toxins (Basel). 2021 Dec 18;13(12):909. doi: 10.3390/toxins13120909. PMID: 34941746; PMCID: PMC8706756.
[6]. Tanaka S, Watanabe H, et,al. Indoxyl Sulfate Contributes to Adipose Tissue Inflammation through the Activation of NADPH Oxidase. Toxins (Basel). 2020 Aug 5;12(8):502. doi: 10.3390/toxins12080502. PMID: 32764271; PMCID: PMC7472142.
[7]. Matsumoto T, Takayanagi K, et,al. Indoxyl sulfate enhances endothelin-1-induced contraction via impairment of NO/cGMP signaling in rat aorta. Pflugers Arch. 2021 Aug;473(8):1247-1259. doi: 10.1007/s00424-021-02581-8. Epub 2021 May 22. Erratum in: Pflugers Arch. 2021 Jun 17;: PMID: 34021781.
[8]. Bolati D, Shimizu H, et,al. Indoxyl sulfate, a uremic toxin, downregulates renal expression of Nrf2 through activation of NF-κB. BMC Nephrol. 2013 Mar 4;14:56. doi: 10.1186/1471-2369-14-56. PMID: 23496811; PMCID: PMC3599003.
[9]. Matsumoto T, Taguchi N, et,al. Indoxyl sulfate decreases uridine adenosine tetraphosphate-induced contraction in rat renal artery. Pflugers Arch. 2022 Dec;474(12):1285-1294. doi: 10.1007/s00424-022-02755-y. Epub 2022 Oct 1. PMID: 36181534.
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