JWH 180

JWH 180 is a potent synthetic cannabinoid (CB) that binds both the central CB1 receptor (Ki = 26 nM) and the peripheral CB2 receptor (Ki = 9.6 nM).[1] The physiological and toxicological properties of JWH 180 have not been characterized. Compounds like JWH 180 have been detected in herbal blends sold as recreational drugs.[2] [3][4] his product is intended for research and forensic applications.

Reference:
[1]. Huffman, J.W., Zengin, G., Wu, M.J., et al. Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB1 and CB2 receptors: Steric and electronic effects of naphthoyl substituents. New highly selective CB2 receptor agonists. Bioorg. Med. Chem. 13, 89-112 (2005).
[2]. Kikura-Hanajiri, R., Uchiyama, N., and Goda, Y. Survey of current trends in the abuse of psychotropic substances and plants in Japan. Leg. Med. (Tokyo) 13(3), 109-115 (2011).
[3]. Ernst, L., Schiebel, H.M., Theuring, C., et al. Identification and characterization of JWH-122 used as new ingredient in "spice-like" herbal incenses. Forensic Science International 208(1-3), e31-35 (2011).
[4]. Uchiyama, N., Kikura-Hanajiri, R., Ogata, J., et al. Chemical analysis of synthetic cannabinoids as designer drugs in herbal products. Forensic Science International 198, 31-38 (2010).