L-Ascorbic Acid 2-phosphate (magnesium salt) (Synonyms: AA2P, Ascorbyl PM, Phospitan C) |
| Catalog No.GC19511 |
L-Ascorbic Acid 2-phosphate (magnesium salt) (2-Phospho-L-ascorbic acid magnesium) is along-actingvitaminCderivativethat can stimulate collagen formation and expression.
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Cas No.: 113170-55-1
Sample solution is provided at 25 µL, 10mM.
L-Ascorbic Acid 2-phosphate (magnesium salt) (AA2P) is a stable VC(vitamin C) derivative[1]. It can stimulate the expression and formation of collagen[2].
L-Ascorbic Acid 2-phosphate (magnesium salt) (100-500μM; 24 h) attenuates MeHg-induced apoptosis by alleviating ROS-mediated DNA damage in SH-SY5Y cell [3]. L-Ascorbic Acid 2-phosphate (magnesium salt) (0.25-1mM) repressed dihydrotestosterone (DHT)-induced DHT-inducible dickkopf-1 (DKK-1) protein expression[4]. L-Ascorbic Acid 2-phosphate (magnesium salt) (250μM; 5-60min) co-treatment with FGF-2 induced optimal proliferation of Human bone marrow mesenchymal stem cells (BMSC) and increased the accumulation rate of BMSC numbers during a 2-month culture period[5]. IGF-1 mRNA in Dermal papilla (DP) cells was upregulated and IGF-1 protein in the conditioned medium of DP cells was significantly increased after treatment with L-Ascorbic Acid 2-phosphate (magnesium salt), L-Ascorbic Acid 2-phosphate (magnesium salt)-inducible IGF-1 from DP cells promotes proliferation of follicular keratinocytes and stimulates hair follicle growth in vitro via PI3K[6].
L-Ascorbic Acid 2-phosphate (magnesium salt) regulate mesenchymal–epithelial interactions in the hair follicle and promote hair growth in mice models[7].
References:
[1]. Spiclin P, Homar M, et,al. Sodium ascorbyl phosphate in topical microemulsions. Int J Pharm. 2003 Apr 30;256(1-2):65-73. doi: 10.1016/s0378-5173(03)00063-2. PMID: 12695012.
[2]. Shima N, Kimoto M, et,al. Increased proliferation and replicative lifespan of isolated human corneal endothelial cells with L-ascorbic acid 2-phosphate. Invest Ophthalmol Vis Sci. 2011 Nov 7;52(12):8711-7. doi: 10.1167/iovs.11-7592. PMID: 21980003.
[3]. Zuo K, Xu Q, et,al. L-Ascorbic Acid 2-Phosphate Attenuates Methylmercury-Induced Apoptosis by Inhibiting Reactive Oxygen Species Accumulation and DNA Damage in Human SH-SY5Y Cells. Toxics. 2023 Feb 2;11(2):144. doi: 10.3390/toxics11020144. PMID: 36851019; PMCID: PMC9967424.
[4]. Kwack MH, Kim MK, et,al. L-ascorbic acid 2-phosphate represses the dihydrotestosterone-induced dickkopf-1 expression in human balding dermal papilla cells. Exp Dermatol. 2010 Dec;19(12):1110-2. doi: 10.1111/j.1600-0625.2010.01143.x. PMID: 20701628.
[5]. Bae SH, Ryu H, et,al. L-ascorbic acid 2-phosphate and fibroblast growth factor-2 treatment maintains differentiation potential in bone marrow-derived mesenchymal stem cells through expression of hepatocyte growth factor. Growth Factors. 2015 Apr;33(2):71-8. doi: 10.3109/08977194.2015.1013628. Epub 2015 Feb 25. PMID: 25714612.
[6]. Kwack MH, Shin SH, et,al. l-Ascorbic acid 2-phosphate promotes elongation of hair shafts via the secretion of insulin-like growth factor-1 from dermal papilla cells through phosphatidylinositol 3-kinase. Br J Dermatol. 2009 Jun;160(6):1157-62. doi: 10.1111/j.1365-2133.2009.09108.x. Epub 2009 Mar 26. PMID: 19416266.
[7]. Sung YK, Hwang SY, et,al. The hair growth promoting effect of ascorbic acid 2-phosphate, a long-acting Vitamin C derivative. J Dermatol Sci. 2006 Feb;41(2):150-2. doi: 10.1016/j.jdermsci.2005.11.010. Epub 2006 Jan 9. PMID: 16406749.
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