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L-Glutamic acid monosodium salt (Monosodium glutamate)

Catalog No.GC30788

L-Glutamic acid monosodium salt (Monosodium glutamate) acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA).

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L-Glutamic acid monosodium salt (Monosodium glutamate) Chemical Structure

Cas No.: 142-47-2

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Protocol

Animal experiment:

For toxicity experiments, mice at PND9 (n=3-9 mice per group) are treated as follows. Two groups receive a subcutaneous (s.c.) injection of corn oil, following, 30 min later, by s.c. injection of either saline or L-Glutamic acid monosodium salt (3 g/kg); two additional groups are treated with 3,4-dihydro-2 H-pyrano[2,3-b]quinolin-7-yl-(cis-4-methoxycyclohexyl)-methanone, dissolving in corn oil (2.5 mg/kg) following, 30 min later, by a s.c. injection of either saline or L-Glutamic acid monosodium salt. In another set of experiments, four groups of crv4 mice or their wild-type littermates (n=5-7 mice per group) are injected s.c. with either saline or L-Glutamic acid monosodium salt (3 g/kg)[1].

References:

[1]. Liberatore F, et al. Permissive role for mglu1 metabotropic glutamate receptors in excitotoxic retinal degeneration. Neuroscience. 2017 Sep 14. pii: S0306-4522(17)30640-1.

Background

L-Glutamic acid monosodium salt (Monosodium glutamate) is an activator of mGlu1 receptor.

A single systemic injection of L-Glutamic acid monosodium salt (MSG) (3 g/kg) to PND9 mice causes extensive retinal degeneration and reduces the number of Brn-3a+RGCs by >70% with respect to control mice treated with saline; In mice treated with L-Glutamic acid monosodium salt and JNJ16259685, the number of RGC is reduced by only <20%, and the resulting value is not significantly different from values obtained in all other groups of mice, including control mice. L-Glutamic acid monosodium salt administration to wild-type BALB/c littermates reduces RGC number to a lower extent than in C57BL/6J mice, but the reduction is still highly significant[1].

[1]. Liberatore F, et al. Permissive role for mglu1 metabotropic glutamate receptors in excitotoxic retinal degeneration. Neuroscience. 2017 Sep 14. pii: S0306-4522(17)30640-1.

Chemical Properties

Cas No. 142-47-2 SDF
Canonical SMILES [O-]C(CC[C@H](N)C(O)=O)=O.[Na+]
Formula C5H8NNaO4 M.Wt 169.11
Solubility Water : ≥ 100 mg/mL (591.33 mM) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 5.9133 mL 29.5666 mL 59.1331 mL
5 mM 1.1827 mL 5.9133 mL 11.8266 mL
10 mM 0.5913 mL 2.9567 mL 5.9133 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Average Rating: 5 ★★★★★ (Based on Reviews and 31 reference(s) in Google Scholar.)

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