Home>>Large T antigen - rhesus polyomavirus 560-568

Large T antigen - rhesus polyomavirus 560-568 (Synonyms: H2N-Ser-Glu-Phe-Leu-Leu-Glu-Lys-Arg-Ile-OH )

Catalog No.GP10037

Large T antigen

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Large T antigen - rhesus polyomavirus 560-568 Chemical Structure

Size Price Stock Qty
1mg
$35.00
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5mg
$104.00
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10mg
$195.00
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25mg
$257.00
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Sample solution is provided at 25 µL, 10mM.

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Quality Control & SDS

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Background

Large T antigen - rhesus polyomavirus 560-568 has a peptide sequence of Ser-Glu-Phe-Leu-Leu-Glu-Lys-Arg-Ile.

T antigen is required for viral DNA replication, transcription, and virion assembly. In addition, T antigen targets multiple cellular pathways, including those that regulate cell proliferation, cell death, and the inflammatory response. The large T-antigen plays a key role in regulating the viral life cycle by binding to the viral origin of DNA replication where it promotes DNA synthesis. Also as the polyomavirus relies on the host cell machinery to replicate the host cell needs to be in s-phase for this to begin. Due to this, large T-antigen also modulates cellular signaling pathways to stimulate progression of the cell cycle by binding to a number of cellular control proteins.

Polyomaviruses have been extensively studied as tumor viruses in humans and animals, leading to fundamental insights into carcinogenesis, DNA replication and protein processing. The tumor suppressor molecule p53 was discovered, for example, as a cellular protein bound by the major oncoprotein (cancer-causing protein) T antigen made by Simian vacuolating virus 40 (SV40).

References:
1. An P, Saenz Robeles MT, Pipas JM. pLarge T antigens of polyomaviruses: amazing molecular machinesq. Annu Rev Microbiol. 2012; 66:213-36.
2. White MK, Gordon J, Reiss K, et al. (December 2005). "Human polyomaviruses and brain tumors". Brain Research. Brain Research Reviews 50 (1): 69-85.

Chemical Properties

Cas No. SDF
Synonyms H2N-Ser-Glu-Phe-Leu-Leu-Glu-Lys-Arg-Ile-OH
Canonical SMILES N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@@H](C)CC)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CO
Formula C52H87N13O15 M.Wt 1134.33
Solubility ≥113.4mg/mL in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 0.8816 mL 4.4079 mL 8.8158 mL
5 mM 0.1763 mL 0.8816 mL 1.7632 mL
10 mM 0.0882 mL 0.4408 mL 0.8816 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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