LY3039478 (Synonyms: LY3039478) |
| Catalog No.GC12653 |
A Notch inhibitor
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1421438-81-4
Sample solution is provided at 25 µL, 10mM.
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LY3039478 is a novel and potent Notch inhibitor with IC50 of 0.41 nM.
The novel and unique Notch Inhibitor, LY3039478, has progressed into clinical development by Lilly co. ltd. LY3039478 displays the best overall profile and is unique within the SAR investigated. LY3039478 Displays Interesting Atropisomer Phenomena. The average LY3039478 major/minor rotational isomer ratio ranged between 14 and 28 in plasma. The crystalline monohydrate form of LY3039478 consists of a single rotational isomer and is chemically and physically stable for at least 14 days under accelerated stability test conditions.
Reference:
[1].Warren J. Porter. Discovery of a Novel Notch Inhibitor. The 8th SCI-RSC Symposium on Proteinase Inhibitor Design April 15-16, 2013, Basel, Switzerland.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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