| Methoxy-X04 Catalog No.GC10894 |
Sample solution is provided at 25 µL, 10mM.
Quality Control & SDS
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Purity = 95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
| Cas No. | 863918-78-9 | SDF | |
| Synonyms | N/A | ||
| Chemical Name | 4,4'-((1E,1'E)-(2-methoxy-1,4-phenylene)bis(ethene-2,1-diyl))diphenol | ||
| Canonical SMILES | COC1=C(C=CC(/C([H])=C([H])/C2=CC=C(O)C=C2)=C1)/C([H])=C([H])/C3=CC=C(O)C=C3 | ||
| Formula | C23H20O3 | M.Wt | 344.4 |
| Solubility | 5 mg/ml in ethanol; 30 mg/ml in DMSO and DMF | Storage | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. | ||
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
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Methoxy-X04 is a brain-permeable fluorescent probe for amyloid-β (Aβ) to detect and quantify plaques, tangles, and cerebrovascular amyloid.1 It displays high in vitro binding affinity (Ki = 26.8 nM) for fibrillar β-sheet deposits and is used to image Aβ plaques in the brains of living APP/PS1 mice, a transgenic model of familial Alzheimer's disease.[1],[2] For in vivo imaging, APP/PS1 mice were injected with methoxy-X04 at a dose of 10 mg/kg, i.p., 24 hours prior to two-photon imaging.2 Methoxy-X04 displays an excitation peak at 750 nm with emission between 460 and 500 nm.[2]
Reference:
[1]. Klunk, W.E., Backsai, B.J., Mathis, C.A., et al. Imaging Aβ plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative. J. Neuropathol. Exp. Neurol. 61(9), 797-805 (2002).
[2]. Burgold, S., Bittner, T., Dorostkar, M.M., et al. In vivo multiphoton imaging reveals gradual growth of newborn amyloid plaques over weeks. Acta. Neuropathol. 121(3), 327-335 (2011).