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ML 145

Catalog No.GC17174

GPR35 antagonist

Products are for research use only. Not for human use. We do not sell to patients.

ML 145 Chemical Structure

Cas No.: 1164500-72-4

Size Price Stock Qty
10mg
$180.00
Ship Within 7 Days
50mg
$675.00
Ship Within 7 Days

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

ML 145 is a selective GPR35/CXCR8 antagonist with an IC50/EC50 of 20.1 nM, but not for the related GPR55 orphan receptor[1]. GPR35 is expressed by various cells of the immune system and it may has potential as a therapeutic target in inflammatory disease[2].

References:
[1]. Heynen-Genel S, et al. Selective GPR35 Antagonists - Probes 1 & 2. National Center for Biotechnology Information (US); 2010-2010 Feb 28.
[2]. Binti Mohd Amir NAS, et al. Evidence for the Existence of a CXCL17 Receptor Distinct from GPR35. J Immunol. 2018 Jul 15;201(2):714-724.

Chemical Properties

Cas No. 1164500-72-4 SDF
Chemical Name 2-hydroxy-4-((Z)-(1-hydroxy-4-((Z)-5-((E)-2-methyl-3-phenylallylidene)-4-oxo-2-thioxothiazolidin-3-yl)butylidene)amino)benzoic acid
Canonical SMILES CC(/C([H])=C(S1)/C(N(C1=S)CCC/C(O)=N/C2=CC(O)=C(C(O)=O)C=C2)=O)=C([H])\C3=CC=CC=C3
Formula C24H22N2O5S2 M.Wt 482.57
Solubility <48.26mg/ml in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.0722 mL 10.3612 mL 20.7224 mL
5 mM 0.4144 mL 2.0722 mL 4.1445 mL
10 mM 0.2072 mL 1.0361 mL 2.0722 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 6 reference(s) in Google Scholar.)

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