|ML-162 Catalog No.GC44214|
Sample solution is provided at 25 µL, 10mM.
|Cas No.||1035072-16-2||SDF||Download SDF|
|Solubility||1mg/mL in ethanol, 25mg/ml in DMSO, 10mg/mL in DMF||Storage||Store at -20°C|
|General tips||For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.|
|Shipping Condition||Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
ML-162 is a GPX4 inhibitor that is selectively lethal to mutant RAS oncogene-expressing cell lines (IC50s = 25 and 578 nM for HRASG12V-expressing and wild-type BJ fibroblasts, respectively)., It shares a similar structure but is more potent and selective than (1S,3R)-RSL3, a previously reported inhibitor of RAS oncogene-expressing cells.
. Yang, W.S., and Stockwell, B.R. Ferroptosis: Death by lipid peroxidation. Trends Cell Biol. 26(3), 165-176 (2016).
. Weïwer, M., Bittker, J.A., Lewis, T.A., et al. Development of small-molecule probes that selectively kill cells induced to express mutant RAS. Bioorg. Med. Chem. Lett. 22(4), 1822-1826 (2012).