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MMP-8 Inhibitor I (Synonyms: Matrix Metalloproteinase-8 Inhibitor I)

Catalog No.GC18616

MMP-8 Inhibitor I is a selective inhibitor of the neutrophil collagenase matrix metalloproteinase-8 (MMP-8) with an IC50 value of 4 nM.

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MMP-8 Inhibitor I Chemical Structure

Cas No.: 236403-25-1

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1mg
$284.00
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Sample solution is provided at 25 µL, 10mM.

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Product Documents

Quality Control & SDS

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Background

MMP-8 Inhibitor I is a selective inhibitor of the neutrophil collagenase matrix metalloproteinase-8 (MMP-8) with an IC50 value of 4 nM. This inhibitor does not target the activities of other MMPs in vitro. MMP-8 cleaves interstitial collagens and has exhibited activity in atherosclerotic plaques, angiogenesis, and stem cell mobilization. Additionally, MMP-8 expression is observed in normal mammary epithelial cells, whereas a loss of expression is observed in human ductal carcinoma in situ and the deletion of MMP-8 accelerates tumor onset in a mouse model of aggressive breast cancer.

Chemical Properties

Cas No. 236403-25-1 SDF
Synonyms Matrix Metalloproteinase-8 Inhibitor I
Chemical Name (3R)-1,2,3,4-tetrahydro-N-hydroxy-2-[(4-methoxyphenyl)sulfonyl]-3-isoquinolinecarboxamide
Canonical SMILES O=C(NO)[C@@H]1N(S(C2=CC=C(OC)C=C2)(=O)=O)CC3=CC=CC=C3C1
Formula C17H18N2O5S M.Wt 362.4
Solubility DMSO: 200 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.7594 mL 13.7969 mL 27.5938 mL
5 mM 0.5519 mL 2.7594 mL 5.5188 mL
10 mM 0.2759 mL 1.3797 mL 2.7594 mL
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Reviews

Review for MMP-8 Inhibitor I

Average Rating: 5 ★★★★★ (Based on Reviews and 35 reference(s) in Google Scholar.)

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