n-Dodecyl-β-D-maltoside (Synonyms: DDM, Dodecyl Maltoside)

n-Dodecyl β-D-maltoside, as a non-ionic detergent, has mild and non-denaturing properties used for during protein-anesthetic studies.^[1]

In vitro, n-Dodecyl β-D-maltoside specifically interacts with HSA with Kd of 40 μM with a lower affinity than SDS with Kd of 2 μM. ^[1] In vitro efficacy test it shown that the magnitude of interactions between n-dodecyl-beta-D-maltoside and other surfactants followed the order anionic/nonionic > cationic/nonionic > nonionic/nonionic mixtures. In addition, electrolyte reduced synergism between n-dodecyl-beta-D-maltoside and ionic surfactant due to charge neutralization.^[2] In vitro, after exposure to 2 mM n-Dodecyl β-D-maltoside, enterocytes were also generally well preserved, n-Dodecyl β-D-maltoside caused a obvious shortening of the microvilli of villus enterocytes compared with NaC.^[3]

References:
[1]Xu L, et al. n-Dodecyl β-D-maltoside specifically competes with general anesthetics for anesthetic binding sites. J Biomol Struct Dyn. 2014;32(11):1833-40.
[2]Zhang R, et al. Study of mixtures of n-dodecyl-beta-D-maltoside with anionic, cationic, and nonionic surfactant in aqueous solutions using surface tension and fluorescence techniques. J Colloid Interface Sci. 2004 Oct 15;278(2):453-60. 
[3]Danielsen EM, et al. Probing the Action of Permeation Enhancers Sodium Cholate and N-dodecyl-β-D-maltoside in a Porcine Jejunal Mucosal Explant System. Pharmaceutics. 2018 Oct 2;10(4):172.