Home>>Signaling Pathways>> PROTAC>>N33-TEG-COOH (N3-TEG-COOH)

N33-TEG-COOH (N3-TEG-COOH)

Catalog No.GC32955

N33-TEG-COOH (N3-TEG-COOH) (N3-TEG-COOH) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

Products are for research use only. Not for human use. We do not sell to patients.

N33-TEG-COOH (N3-TEG-COOH) Chemical Structure

Cas No.: 201467-81-4

Size Price Stock Qty
10mM (in 1mL DMSO)
$50.00
In stock
100mg
$46.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

N33-TEG-COOH is a PROTAC linker containing four polyethylene glycol (PEG) units.

N33-TEG-COOH is a long linker extracted from Reference PMID: 26035625, Compound 7. A PROTAC is a heterobifunctional compound that contains two ligands connected by a linker unit. One ligand binds an E3 ubiquitin ligase protein, while the other ligand binds to the target protein of interest, thereby bringing the ligase and the target in close proximity[1].

[1]. Zengerle M, et al. Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4. ACS Chem Biol. 2015 Aug 21;10(8):1770-7.

Chemical Properties

Cas No. 201467-81-4 SDF
Canonical SMILES O=C(O)COCCOCCOCCOCCN=[N+]=[N-]
Formula C10H19N3O6 M.Wt 277.27
Solubility DMSO : ≥ 100 mg/mL (360.66 mM) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 3.6066 mL 18.033 mL 36.0659 mL
5 mM 0.7213 mL 3.6066 mL 7.2132 mL
10 mM 0.3607 mL 1.8033 mL 3.6066 mL
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In vivo Formulation Calculator (Clear solution)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Reviews

Review for N33-TEG-COOH (N3-TEG-COOH)

Average Rating: 5 ★★★★★ (Based on Reviews and 4 reference(s) in Google Scholar.)

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