Home>>Signaling Pathways>> Neuroscience Peptides>> Neuroscience>>Nitric Oxide Synthase (599-613) Blocking Peptide, Bovine Endothelial Cell
Nitric Oxide Synthase (599-613) Blocking Peptide, Bovine Endothelial Cell Catalog No.GP10011

Blocker of NO production

Size Price Stock Qty
1mg
$41.00
In stock
5mg
$135.00
In stock
10mg
$210.00
In stock
25mg
$295.00
In stock

Customer Review

Based on customer reviews.

Tel: (626) 353-8530 Email: sales@glpbio.com

Sample solution is provided at 25 µL, 10mM.

Quality Control

Quality Control & SDS

View current batch:

Nitric Oxide Synthase (599-613) Blocking Peptide, Bovine Endothelial Cell Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Nitric Oxide Synthase (599-613) Blocking Peptide, Bovine Endothelial Cell Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Chemical Properties

Cas No. N/A SDF
Synonyms Ac-Pro-Tyr-Asn-Ser-Ser-Pro-Arg-Pro-Glu-Gln-His-Lys-Ser-Tyr-Lys-Cys-OH
Chemical Name N/A
Canonical SMILES O=C(NC(CC1=CC=C(O)C=C1)C(NC(CC(N)=O)C(NC(CO)C(NC(CO)C(N2CCCC2C(NC(CCCNC(N)=N)C(N3CCCC3C(NC(CCC(O)=O)C(NC(CCC(N)=O)C(NC(CC4=CN=CN4)C(NC(CCCCN)C(NC(CO)C(NC(CC5=CC=C(O)C=C5)C(NC(CCCCN)C(NC(CS)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C6CCCN6C(C)=O
Formula C85H127N25O27S M.Wt 1963.13
Solubility ≥196.3mg/mL in DMSO Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

Background

Nitric oxide synthases (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO is an important cellular signaling molecule. It helps modulate vascular tone, insulin secretion, airway tone, and peristalsis, and is involved in angiogenesis and neural development. NOS is known to exist in three isoforms: (a) a soluble constitutively expressed enzyme found in high concentrations in the brain (bNOS, nNOS, or NOS-1), (b) a constitutively expressed endothelial membrane bound enzyme (eNOS or NOS-3), and (c) an inducible enzyme (iNOS or NOS-2) that is associated with the cytotoxic function of macrophages. [1]

Nitric Oxide Synthase (599-613) Blocking Peptide, Bovine Endothelial Cell (Ac-Pro-Tyr-Asn-Ser-Ser-Pro-Arg-Pro-Glu-Gln-His-Lys-Ser-Tyr-Lys-Cys) is a peptide that inhibit the function of NOSs as a result it blocks the production of NO. Because of the involvement of all the three NOS isozymes in various aspects of signal transduction, NOS inhibitors have gained prominence in the management of ischemic reperfusion injury, hypotensive effects of drugs, and inflammatory response to cytokines. [2][3]

References:
1. Achike, F.I., and Kwan, C.Y. 2003. Clin. Exp. Pharmacol. Physiol. 30, 605.
2. Chu, C.J., et al. 2000. Clin. Sci. 99, 475.?
3.Mori. M., and Gotoh, T. 2000. Biochem. Biophys. Res. Commun. 275, 715.