| OSMI-4 Catalog No.GC31517 |
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
-
Purity = 99.18%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
| Cas No. | 2260791-14-6 | SDF | Download SDF |
| Synonyms | N/A | ||
| Chemical Name | N/A | ||
| Canonical SMILES | O=C1C=CC2=C(C=C(Cl)C(S(N[C@@H](C(N(CC(OCC)=O)CC3=CC=CS3)=O)C4=C(OC)C=CC=C4)(=O)=O)=C2)N1 | ||
| Formula | C27H26ClN3O7S2 | M.Wt | 604.09 |
| Solubility | DMSO : 125 mg/mL (206.92 mM; Need ultrasonic) | Storage | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. | ||
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
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OSMI-4 is a low nanomolar O-GlcNAc transferase (OGT) inhibitor, with an EC50 of 3 μM in cells.
OSMI-4 (4b) is the best OGT inhibitor reported to date, with a ∼3 μM EC50 in cells, making it especially attractive for probing OGT’s complex biology[1].
[1]. Martin SES, et al. Structure-Based Evolution of Low Nanomolar O-GlcNAc Transferase Inhibitors. J Am Chem Soc. 2018 Oct 24;140(42):13542-13545.