|OSMI-4 Catalog No.GC31517|
Sample solution is provided at 25 µL, 10mM.
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|Cas No.||2260791-14-6||SDF||Download SDF|
|Solubility||DMSO : 125 mg/mL (206.92 mM; Need ultrasonic)||Storage||Store at -20°C|
|General tips||For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.|
|Shipping Condition||Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
OSMI-4 is a low nanomolar O-GlcNAc transferase (OGT) inhibitor, with an EC50 of 3 μM in cells.
OSMI-4 (4b) is the best OGT inhibitor reported to date, with a ∼3 μM EC50 in cells, making it especially attractive for probing OGT’s complex biology.
. Martin SES, et al. Structure-Based Evolution of Low Nanomolar O-GlcNAc Transferase Inhibitors. J Am Chem Soc. 2018 Oct 24;140(42):13542-13545.