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OSMI-4 Catalog No.GC31517

Size Price Stock Qty
10 mM * 1 mL in DMSO
$777.00
In stock
5mg
$585.00
In stock
10mg
$855.00
In stock
50mg
$2,655.00
In stock
100mg
$3,555.00
In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 2260791-14-6 SDF Download SDF
Synonyms N/A
Chemical Name N/A
Canonical SMILES O=C1C=CC2=C(C=C(Cl)C(S(N[C@@H](C(N(CC(OCC)=O)CC3=CC=CS3)=O)C4=C(OC)C=CC=C4)(=O)=O)=C2)N1
Formula C27H26ClN3O7S2 M.Wt 604.09
Solubility DMSO : 125 mg/mL (206.92 mM; Need ultrasonic) Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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Background

OSMI-4 is a low nanomolar O-GlcNAc transferase (OGT) inhibitor, with an EC50 of 3 μM in cells.

OSMI-4 (4b) is the best OGT inhibitor reported to date, with a ∼3 μM EC50 in cells, making it especially attractive for probing OGT’s complex biology[1].

[1]. Martin SES, et al. Structure-Based Evolution of Low Nanomolar O-GlcNAc Transferase Inhibitors. J Am Chem Soc. 2018 Oct 24;140(42):13542-13545.