Paclitaxel octadecanedioate (Synonyms: 1,18-Octadecanedioic Acid-Paclitaxel, ODDA-PTX, PTX-FA18) |
| Catalog No.GC45758 |
A prodrug form of paclitaxel
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2089211-45-8
Sample solution is provided at 25 µL, 10mM.
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Paclitaxel octadecanedioate is a prodrug form of paclitaxel that is comprised of paclitaxel conjugated to 1,18-octadecanedioic acid.1 Unlike paclitaxel, it does not promote tubulin polymerization in vitro when used at a concentration of 10 μM. A 5:1 mixture of paclitaxel octadecanedioate:human serum albumin (HSA) is cytotoxic to HT-1080, PANC-1, and HT-29 cells (IC50s = 12, 2.48, and 8.62 nM, respectively). This mixture reduces tumor growth and increases survival in an HT-1080 mouse xenograft model in a dose-dependent manner.
|1. Callmann, C.E., Leguyader, C.L.M., Burton, S.T., et al. Antitumor activity of 1,18-octadecanedioic acid-paclitaxel complexed with human serum albumin. J. Am. Chem. Soc. 141(30), 11765-11769 (2019).
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