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Peptide YY(3-36), PYY, human

Catalog No.GP10131

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Peptide YY(3-36), PYY, human Chemical Structure

Cas No.: 123583-37-9

Size Price Stock Qty
1mg
$76.00
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5mg
$224.00
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10mg
$347.00
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25mg
$514.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Peptide YY (PYY) is a short (36-amino acid) peptide released by cells in the ileum and colon in response to feeding. It is also known as peptide tyrosine tyrosine or pancreatic peptide YY3-36. [1]
Studies have shown an important role of PYY (3-36) in the regulation of appetite control. It is the major circulating form of the peptide, is considered to reduce food intake in humans and rodents via high affinity binding to the auto-inhibitory neuropeptide Y receptor Y2R in the hypothalamic arcuate nucleus (ARC), a brain area responsible for the regulation of food intake. PYY (3-36) may represent a promising tool for the treatment of obesity.
PYY exerts its action through NPY receptors; it inhibits gastric motility and increases water and electrolyte absorption in the colon. [2] PYY may also suppress pancreatic secretion. Several studies have shown acute peripheral administration of PYY3-36 inhibits feeding of rodents and primates. Other studies on Y2R-knockout mice have shown no anorectic effect on them. These findings indicate PYY3-36 has an anorectic (losing appetite) effect, which is suggested to be mediated by Y2R. PYY works by slowing the gastric emptying; hence, it increases efficiency of digestion and nutrient absorption after a meal. Research has also indicated PYY may be useful in removing aluminum accumulated in the brain.

References:
1.Entrez Gene: PYY peptide YY
2.DeGroot, Leslie Jacob (1989). In J. E. McGuigan. Endocrinology. Philadelphia: Saunders. p. 2754.

Chemical Properties

Cas No. 123583-37-9 SDF
Formula C180H279N53O54 M.Wt 4049.6
Solubility ≥405mg/mL in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 0.2469 mL 1.2347 mL 2.4694 mL
5 mM 0.0494 mL 0.2469 mL 0.4939 mL
10 mM 0.0247 mL 0.1235 mL 0.2469 mL
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