PF 3084014 hydrobromide (Synonyms: PF-3084014 dihydrobromide; PF-03084014 dihydrobromide) |
| Catalog No.GC50251 |
PF 3084014 hydrobromide (PF-3084014 dihydrobromide) is a reversible, orally bioavailable, noncompetitive, and selective γ-secretase inhibitor with an IC50 of 6.2 nM. Inhibition of Notch signaling by PF 3084014 hydrobromide while minimizing gastrointestinal toxicity presents a promising approach for research of Notch receptor-dependent cancers.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1962925-29-6
Sample solution is provided at 25 µL, 10mM.
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Potent γ-secretase inhibitor (IC50 values are 1.2 and 6.2 nM in whole cell and cell-free assays, respectively). Reduces Aβ in brain, CSF and plasma in mice and guinea pigs.
Lanz et al (2010) Pharmacodynamics and pharmacokinetics of the gamma-secretase inhibitor PF-3084014. J.Pharmacol.Exp.Ther. 334 269 PMID:20363853
Average Rating: 5 (Based on Reviews and 39 reference(s) in Google Scholar.)
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