Home>>Photo-lysine hydrochloride
Photo-lysine hydrochloride Catalog No.GC34295

Size Price Stock Qty
5mg
$1,080.00
In stock
10mg
$1,944.00
In stock
20mg
$3,240.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Photo-lysine hydrochloride Dilution Calculator

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Photo-lysine hydrochloride Molarity Calculator

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Chemical Properties

Cas No. N/A SDF Download SDF
Synonyms N/A
Chemical Name N/A
Canonical SMILES O=C(O)[C@@H]([NH3+])CC1(N=N1)CC[NH3+].[Cl-].[Cl-]
Formula C6H14Cl2N4O2 M.Wt 245.11
Solubility H2O : ≥ 40 mg/mL (163.19 mM) Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

Background

Photo-lysine hydrochloride, a new lysine-based photo-reactive amino acid, captures proteins that bind lysine post-translational modifications.

Photo-lysine is designed and synthesized by incorporating a photo-cross-linker (diazirine) into the side chain of natural lysine. Photo-lysine, which is readily incorporated into proteins by native mammalian translation machinery, can be used to capture and identify proteins that recognize lysine post-translational modifications (PTMs), including ’readers’ and ’erasers’ of histone modifications. Photo-lysine can be incorporated into MDH2 and mediate photo-cross-linking to fix protein-protein interactions in cells. UV irradiation of cells in the presence of photo-lysine induced robust cross-linking of HSP90β and HSP60. Photo-lysine has higher efficiency than photo-leucine for photo-cross-linking of the two chaperone proteins. Photo-lysine enables capture of the heterodimer of proteins Ku70 and Ku80 within a protein complex. Photo-lysine enables identification of histone- and chromatin-binding proteins[1].

[1]. Yang T, et al. Photo-lysine captures proteins that bind lysine post-translational modifications. Nat Chem Biol. 2016 Feb;12(2):70-2.