QL-IX-55 |
| Catalog No.GC18032 |
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1223002-54-7
Sample solution is provided at 25 µL, 10mM.
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The functional target of QL-IX-55 is the ATP-binding site of TOR2 as evidenced by the discovery of resistant alleles of TOR2 through rational design and unbiased selection strategies. QL-IX-55 is capable of potently inhibiting both TOR complex 1 and 2 (TORC1 and TORC2) as demonstrated by biochem. IP kinase assays (IC50 <50 nM) and cellular assays for inhibition of substrate YPK1 phosphorylation. In contrast to rapamycin, QL-IX-55 is capable of inhibiting TORC2-dependent transcription, which suggests that this compd. will be a powerful probe to dissect the Tor2/TORC2-related signaling pathway in yeast.
Review for QL-IX-55
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
Review for QL-IX-55
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