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Angiogenesis

Products for  Angiogenesis

  1. Cat.No. Product Name Information
  2. GC13812 PCI-32765 (Ibrutinib)

    PCI-32765 (Ibrutinib) is an irreversible selective inhibitor of Bruton s tyrosine kinase (BTK) that selectively targets its kinase domain.

    PCI-32765 (Ibrutinib)  Chemical Structure
  3. GC12921 PCI-32765 Racemate PCI-32765 Racemate (PCI-32765 Racemate) is the racemate of Ibrutinib. Ibrutinib is a selective, irreversible Btk inhibitor with IC50 value of 0.5 nM. PCI-32765 Racemate  Chemical Structure
  4. GC30155 PCI-33380 PCI-33380 is an irreversible and selective Bruton's Tyrosine Kinase (BTK) inhibitor (fluorescent probe). PCI-33380  Chemical Structure
  5. GC44584 PD 168368 PD 168368 is a competitive antagonist of neuromedin B (NMB) receptors (Kis = 15-45 nM for rat and human receptors expressed in various cell lines). PD 168368  Chemical Structure
  6. GC34709 PF-06250112 PF-06250112 is a potent, highly selective, orally bioavailable BTK inhibitor with an IC50 of 0.5 nM, shows inhibitory effect toward BMX nonreceptor tyrosine kinase and TEC with IC50s of 0.9 nM and 1.2 nM, respectively. PF-06250112  Chemical Structure
  7. GC62515 Pirtobrutinib Pirtobrutinib (LOXO-305), a highly selective and non-covalent next generation BTK inhibitor, inhibits diverse BTK C481 substitution mutations. Pirtobrutinib causes regression of BTK-dependent lymphoma tumors in mouse xenograft models. Pirtobrutinib is also more than 300-fold selective for BTK versus 370 other kinases tested and shows no significant inhibition of non-kinase off-targets at 1 μM. Pirtobrutinib  Chemical Structure
  8. GC10235 Plinabulin (NPI-2358) Plinabulin (NPI-2358) (NPI-2358) is a vascular disrupting agen (VDA) against tubulin-depolymerizing with an IC50 of 9.8 nM against HT-29 cells. Plinabulin (NPI-2358) binds the colchicine binding site of β-tubulin preventing polymerization and has potent inhibitory to tumor cells. Plinabulin (NPI-2358)  Chemical Structure
  9. GC67708 PLN-1474 PLN-1474  Chemical Structure
  10. GC47965 Pomalidomide-d5 An internal standard for the quantification of pomalidomide Pomalidomide-d5  Chemical Structure
  11. GC47966 PPACK (trifluoroacetate salt) An antithrombin peptide PPACK (trifluoroacetate salt)  Chemical Structure
  12. GC31339 PRN1008 PRN1008 (PRN1008) is a reversible covalent, selective and oral active inhibitor of Bruton's Tyrosine Kinase (BTK), with an IC50 of 1.3 nM. PRN1008  Chemical Structure
  13. GC47980 Propionyl-L-carnitine-d3 (chloride)

    An internal standard for the quantification of propionyl-L-carnitine

    Propionyl-L-carnitine-d3 (chloride)  Chemical Structure
  14. GC69768 Protease-Activated Receptor-1, PAR-1 Agonist

    Protease-Activated Receptor-1, PAR-1 Agonist is a selective peptide that activates Protease-Activated Receptor-1 (PAR-1), which corresponds to the PAR1 ligand and selectively mimics the action of thrombin through this receptor.

    Protease-Activated Receptor-1, PAR-1 Agonist  Chemical Structure
  15. GC62469 Protease-Activated Receptor-1, PAR-1 Agonist TFA Protease-Activated Receptor-1, PAR-1 Agonist TFA is a selective proteinase-activated receptor1 (PAR-1) agonist peptide. Protease-Activated Receptor-1, PAR-1 Agonist TFA corresponds to PAR1 tethered ligand and which can selectively mimic theactions of thrombin via this receptor. Protease-Activated Receptor-1, PAR-1 Agonist TFA  Chemical Structure
  16. GC61456 Protease-Activated Receptor-3 (PAR-3) (1-6), human TFA Protease-Activated Receptor-3 (PAR-3) (1-6), human TFA is a proteinase-activated receptor (PAR-3) agonist peptide. Protease-Activated Receptor-3 (PAR-3) (1-6), human TFA  Chemical Structure
  17. GC33429 Protease-Activated Receptor-4 Protease-Activated Receptor-4 is the agonist of proteinase-activated receptor-4 (PAR4). Protease-Activated Receptor-4  Chemical Structure
  18. GC49873 Protectin D1 methyl ester An esterified form of protectin D1 Protectin D1 methyl ester  Chemical Structure
  19. GC32680 PT-2385 PT-2385 is a selective HIF-2α inhibitor with a Ki of less than 50 nM. PT-2385  Chemical Structure
  20. GC37034 PT2977 PT2977 (PT2977) is an orally active and selective HIF-2α inhibitor with an IC50 of 9 nM. PT2977, as a second-generation HIF-2α inhibitor, increases potency and improves pharmacokinetic profile. PT2977 is a potential treatment for clear cell renal cell carcinoma (ccRCC). PT2977  Chemical Structure
  21. GC11031 PX-478 2HCl

    PX-478 is a selective inhibitor that suppresses constitutive and hypoxia-induced HIF-1α levels.

    PX-478 2HCl  Chemical Structure
  22. GC37048 QL47 QL47, a broad-spectrum antiviral agent, inhibits dengue virus and other RNA viruses. QL47  Chemical Structure
  23. GC49221 QLT0267 An ILK inhibitor QLT0267  Chemical Structure
  24. GC44800 Quininib A CysLT1 and CysLT2 receptor antagonist Quininib  Chemical Structure
  25. GC37066 Rac-PT2399 A potent and specific HIF-2α inhibitor Rac-PT2399  Chemical Structure
  26. GC40213 Regorafenib-13C-d3 Regorafenib-13C-d3 is intended for use as an internal standard for the quantification of regorafenib by GC- or LC-MS. Regorafenib-13C-d3  Chemical Structure
  27. GC38375 Remibrutinib Remibrutinib, is a potent and orally active bruton tyrosine kinase (BTK) inhibitor with an IC50 value of 1 nM. Remibrutinib  Chemical Structure
  28. GC10184 RGD (Arg-Gly-Asp) Peptides RGD (Arg-Gly-Asp) Peptides is a tripeptide that effectively triggers cell adhesion, addresses certain cell lines and elicits specific cell responses; binds to integrins. RGD (Arg-Gly-Asp) Peptides  Chemical Structure
  29. GC37524 RGD peptide (GRGDNP) TFA RGD peptide (GRGDNP) TFA  Chemical Structure
  30. GC34402 RGD Trifluoroacetate RGD Trifluoroacetate is a tripeptide that effectively triggers cell adhesion, addresses certain cell lines and elicits specific cell responses; RGD Trifluoroacetate binds to integrins. RGD Trifluoroacetate  Chemical Structure
  31. GC16385 RGDS peptide RGDS peptide is an integrin binding sequence that inhibits integrin receptor function. RGDS peptide  Chemical Structure
  32. GC45798 Rhein-13C4 An internal standard for the quantification of rhein Rhein-13C4  Chemical Structure
  33. GC37541 Risuteganib Risuteganib  Chemical Structure
  34. GC17991 RLLFT-NH2 Protease-activated receptor agonist RLLFT-NH2  Chemical Structure
  35. GC11230 RN486 Btk inhibitor,potent and selective RN486  Chemical Structure
  36. GC62397 RO0270608 RO0270608, the active metabolite of R411, is a dual alpha4beta1-alpha4beta7 (α4β1/α4β7) integrin antagonist. RO0270608  Chemical Structure
  37. GC14795 RWJ 50271 LFA-1/sICAM interaction inhibitor RWJ 50271  Chemical Structure
  38. GC61777 RWJ-56110 dihydrochloride RWJ-56110 dihydrochloride is a potent, selective, peptide-mimetic inhibitor of PAR-1 activation and internalization (binding IC50=0.44 uM) and shows no effect on PAR-2, PAR-3, or PAR-4. RWJ-56110 dihydrochloride  Chemical Structure
  39. GC14143 SB273005

    An αvβ3 antagonist

    SB273005  Chemical Structure
  40. GC10291 SCH 79797 dihydrochloride PAR1 receptor antagonist SCH 79797 dihydrochloride  Chemical Structure
  41. GC63540 SCH79797 SCH79797 is a highly potent, selective nonpeptide protease activated receptor 1 (PAR1) antagonist. SCH79797  Chemical Structure
  42. GC64571 Sibrafiban Sibrafiban (RO 48-3657) is the orally active, nonpeptide, double-prodrug of Ro 44-3888 and a selective glycoprotein IIb/IIIa receptor antagonist. Sibrafiban  Chemical Structure
  43. GC49713 SIKVAV (acetate) A laminin α1-derived peptide SIKVAV (acetate)  Chemical Structure
  44. GC49358 Sildenafil Chlorosulfonyl An intermediate in the synthesis of sildenafil Sildenafil Chlorosulfonyl  Chemical Structure
  45. GC48078 Sildenafil-d3 An internal standard for the quantification of sildenafil Sildenafil-d3  Chemical Structure
  46. GC62614 SJF620 hydrochloride SJF620 hydrochloride is a PROTAC connected by ligands for Cereblon and Btk with a DC50 of 7.9 nM. SJF620 contains a Lenalidomide analog for recruiting CRBN. SJF620 hydrochloride  Chemical Structure
  47. GC14540 SLIGKV-NH2 SLIGKV-NH2 (SLIGKV-NH2) is a highly potent protease-activated receptor-2 (PAR2) activating peptide. SLIGKV-NH2  Chemical Structure
  48. GC17514 SLIGRL-NH2 PAR2 activator SLIGRL-NH2  Chemical Structure
  49. GC37672 Spebrutinib besylate Spebrutinib besylate (AVL-292 benzenesulfonate; CC-292 besylate) is a potent inhibitor of Btk kinase activity (IC50<0.5 nM, Kinact/Ki=7.69×104 M-1s-1s) in biochemical assays. Spebrutinib besylate  Chemical Structure
  50. GC40963 Spirolaxine Spirolaxine is a long-chain phthalide produced by the fungus S. Spirolaxine  Chemical Structure
  51. GC31993 SR121566A SR121566A is a novel non-peptide Glycoprotein IIb/IIIa (GP IIb-IIIa) antagonist, which can inhibit ADP-, arachidonic acid- and collagen-induced human platelet aggregation with IC50s of 46±7.5, 56±6 and 42±3 nM, respectively. SR121566A  Chemical Structure
  52. GC44956 Streptochlorin Streptochlorin is a bacterial metabolite originally isolated from Streptomyces sp. Streptochlorin  Chemical Structure
  53. GC45688 STX140 An estrogen sulfamate STX140  Chemical Structure
  54. GC44966 Sucrose octasulfate (potassium salt) Sucrose octasulfate (SOS), a component of the gastrointestinal protectant sucralfate, is an alkaline aluminum-sucrose complex that inhibits peptic hydrolysis and raises gastric pH, protecting esophageal epithelium against acid injury. Sucrose octasulfate (potassium salt)  Chemical Structure
  55. GC32876 SYP-5 A HIF-1 inhibitor SYP-5  Chemical Structure
  56. GC64120 TAK-020 TAK-020 is a covalent Btk inhibitor, which becomes the clinical candidate. TAK-020  Chemical Structure
  57. GC12037 TC-I 15 α2β1 integrin inhibitor TC-I 15  Chemical Structure
  58. GC18025 TCS 2314 integrin very late antigen-4 (VLA-4; α4β1) antagonist TCS 2314  Chemical Structure
  59. GC61316 tcY-NH2 TFA tcY-NH2 ((trans-Cinnamoyl)-YPGKF-NH2) TFA is a potent selective PAR4 antagonist peptide. tcY-NH2 TFA  Chemical Structure
  60. GC61323 Tetrac Tetrac (Tetraiodothyroacetic acid), a derivative of L-thyroxine (T4), is a thyrointegrin receptor antagonist. Tetrac blocks the actions of T4 and 3,5,3'-triiodo-L-thyronine (T3) at the cell surface receptor for thyroid hormone on integrin αvβ3. Tetra has anti-angiogenic and anti-tumor activities. Tetrac  Chemical Structure
  61. GC17444 TFLLR-NH2 PAR1 selective agonist TFLLR-NH2  Chemical Structure
  62. GC37770 TFLLR-NH2(TFA) TFLLR-NH2 (TFA) is a selective PAR1 agonist with an EC50 of 1.9 μM. TFLLR-NH2(TFA)  Chemical Structure
  63. GP10085 Thrombin Receptor Activator for Peptide 5 (TRAP-5) Thrombin Receptor Activator for Peptide 5 (TRAP-5)  Chemical Structure
  64. GC10140 Thrombin Receptor Agonist Peptide Thrombin Receptor Agonist Peptide is a synthetic thrombin receptor agonist peptide. Thrombin Receptor Agonist Peptide  Chemical Structure
  65. GC32945 THS-044 THS-044 binding stabilizes the HIF2α PAS-B folded state, for regulating HIF2 activity in endogenous and clinical settings. THS-044  Chemical Structure
  66. GC45054 Tie2 Inhibitor 7 Tie2 Inhibitor 7 blocks Tie2 kinase activity with a Ki value of 1.3 μM.. Tie2 Inhibitor 7  Chemical Structure
  67. GC32228 Tilorone dihydrochloride An interferon-inducing antiviral agent Tilorone dihydrochloride  Chemical Structure
  68. GC33821 Tirabrutinib (ONO-4059) Tirabrutinib (ONO-4059) (ONO-4059) is an orally active Bruton's Tyrosine Kinase (BTK) inhibitor (can cross the blood-brain barrier (BBB)), with an IC50 of 6.8 nM. Tirabrutinib (ONO-4059)  Chemical Structure
  69. GC34097 Tirabrutinib hydrochloride (ONO-4059 (hydrochloride)) Tirabrutinib (ONO-4059) hydrochloride is an orally active Bruton's Tyrosine Kinase (BTK) inhibitor (can cross the blood-brain barrier (BBB)), with an IC50 of 6.8 nM. Tirabrutinib hydrochloride (ONO-4059 (hydrochloride))  Chemical Structure
  70. GC13255 Tirofiban selective platelet GPIIb/IIIa antagonist Tirofiban  Chemical Structure
  71. GC11371 Tirofiban hydrochloride monohydrate A GPIIb/IIIa antagonist Tirofiban hydrochloride monohydrate  Chemical Structure
  72. GC63229 TL-895 TL-895 is a potent, orally active, ATP-competitive, and highly selective irreversible BTK inhibitor with an IC50 and a Ki of 1.5 nM and 11.9 nM, respectively. TL-895  Chemical Structure
  73. GC37801 TM6089 TM6089 is a unique Prolyl Hydroxylase (PHD) inhibitor which stimulates HIF activity without iron chelation and induces angiogenesis and exerts organ protection against ischemia. TM6089  Chemical Structure
  74. GC63232 Tolebrutinib Tolebrutinib (SAR442168) is a potent, selective, orally active and brain-penetrant inhibitor of Bruton tyrosine kinase (BTK), with IC50s of 0.4 and 0.7 nM in Ramos B cells and in HMC microglia cells, respectively. Tolebrutinib  Chemical Structure
  75. GC31498 TP0463518

    TP0463518 is a potent hypoxia-inducible factor prolyl hydroxylases (PHDs) inhibitor

    TP0463518  Chemical Structure
  76. GC37818 TR-14035 TR-14035 is a orally active dual α4β7/α4β1 integrin antagonist, with IC50 s of 7 nM and 87 nM for α4β7 and α4β1, respectively. TR-14035  Chemical Structure
  77. GC48195 trans-trismethoxy Resveratrol-d4 An internal standard for the quantification of trans-trismethoxy resveratrol trans-trismethoxy Resveratrol-d4  Chemical Structure
  78. GC11662 TRAP-6

    PAR1 agonist

    TRAP-6  Chemical Structure
  79. GC65529 TRAP-6 amide TRAP-6 amide is a PAR-1 thrombin receptor agonist peptide. TRAP-6 amide  Chemical Structure
  80. GC48210 TRX-818 (sodium salt) An anticancer compound TRX-818 (sodium salt)  Chemical Structure
  81. GC37852 UDM-001651 UDM-001651 is a potent, selective, and orally bioavailable protease-activated receptor 4 (PAR4) antagonist (IC50=4 nM; Kd=1.4 nM). UDM-001651  Chemical Structure
  82. GC16811 Vadadustat HIF-PH inhibitor Vadadustat  Chemical Structure
  83. GC63490 Valategrast Valategrast (R-411 free base) is a potent and orally active integrin α4β1 (VLA-4) and α4β7 dual antagonist. Valategrast  Chemical Structure
  84. GC64212 Valategrast hydrochloride Valategrast hydrochloride (R-411) is a potent integrin α4β1 (VLA-4) and α4β7 dual antagonist. Valategrast hydrochloride  Chemical Structure
  85. GC45769 Vandetanib-d6 An internal standard for the quantification of vandetanib Vandetanib-d6  Chemical Structure
  86. GC37889 VCE-004.8 VCE-004.8 (VCE-004.8) is an orally active, specific PPARγ and CB2 receptor dual agonist. VCE-004.8  Chemical Structure
  87. GC34077 Vecabrutinib (SNS-062) Vecabrutinib (SNS-062) (SNS-062) is a potent, noncovalent BTK and ITK inhibitor, with Kd values of 0.3 nM and 2.2 nM, respectively. Vecabrutinib (SNS-062) shows an IC50 of 24 nM for ITK. Vecabrutinib (SNS-062)  Chemical Structure
  88. GC34211 Vedolizumab Vedolizumab is a humanized IgG1 monoclonal antibody that targets the α4β7 integrin for the treatment of ulcerative colitis and Crohn's disease. Vedolizumab  Chemical Structure
  89. GC11727 VKGILS-NH2 control peptide for SLIGKV-NH2, PAR1 agonist VKGILS-NH2  Chemical Structure
  90. GC17545 Vorapaxar PAR-1 antagonist,potent and orally active Vorapaxar  Chemical Structure
  91. GC64347 Vorapaxar sulfate Vorapaxar sulfate (SCH 530348 sulfate), an antiplatelet agent, is a selective, orally active, and competitive thrombin receptor protease-activated receptor (PAR-1) antagonist (Ki=8.1 nM). Vorapaxar sulfate  Chemical Structure
  92. GC34075 Zanubrutinib (BGB-3111) Zanubrutinib (BGB-3111) (BGB-3111) is a selective Bruton tyrosine kinase (Btk) inhibitor. Zanubrutinib (BGB-3111)  Chemical Structure
  93. GC37960 Zaurategrast Zaurategrast (CT7758) is a potent and oral-effective α4-integrin inhibitor. Zaurategrast  Chemical Structure
  94. GC37961 Zaurategrast ethyl ester Zaurategrast ethyl ester (CDP323), the ethyl ester prodrug of CT7758, is a α4β1/α4β7 integrin antagonist used for the treatment of inflammatory and autoimmune disorders. Zaurategrast ethyl ester  Chemical Structure
  95. GC37962 Zaurategrast ethyl ester sulfate Zaurategrast ethyl ester sulfate (CDP323 sulfate), the ethyl ester prodrug of CT7758, is a α4β1/α4β7 integrin antagonist used for the treatment of inflammatory and autoimmune disorders. Zaurategrast ethyl ester sulfate  Chemical Structure
  96. GC37966 ZINC13466751 ZINC13466751 is a potent inhibitor of HIF-1α/von Hippel-Lindau interaction with an IC50 of 2.0 ?M. ZINC13466751  Chemical Structure

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