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Home >> Signaling Pathways >> Apoptosis >> Bcl-2 Family

Bcl-2 Family

Bcl-2 family proteins are a group of proteins homologous to the Bcl-2 protein and characterized by containing at least one of four conserved Bcl-2 homology (BH) domains (BH1, BH2, BH3 and BH4). Bcl-2 family proteins, consisting of pro-apoptotic and anti-apoptotic molecules, can be classified into the following three subfamilies according to sequence homology within four BH domains: (1) a subfamily shares sequence homology within all four BH domains, such as Bcl-2, Bcl-XL and Bcl-w which are anti-apoptotic; (2) a subfamily shares sequence homology within BH1, BH2 and BH4, such as Bax and Bak which are pro-apoptotic; (3) a subfamily shares sequence homology only within BH3, such as Bik and Bid which are pro-apoptotic.

Products for  Bcl-2 Family

  1. Cat.No. Product Name Information
  2. GC17008 (+)-Apogossypol inhibitor of Bcl-2 family proteins (+)-Apogossypol Chemical Structure
  3. GC34980 (E)-Ferulic acid (E)-Ferulic acid is a isomer of Ferulic acid which is an aromatic compound, abundant in plant cell walls. (E)-Ferulic acid causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin. (E)-Ferulic acid shows a potent ability to remove reactive oxygen species (ROS) and inhibits lipid peroxidation. (E)-Ferulic acid exerts both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299. (E)-Ferulic acid Chemical Structure
  4. GC34096 (R)-(-)-Gossypol acetic acid (AT-101 (acetic acid)) (R)-(-)-Gossypol acetic acid (AT-101 (acetic acid)) (AT-101 (acetic acid)) is the levorotatory isomer of a natural product Gossypol. AT-101 is determined to bind to Bcl-2, Mcl-1 and Bcl-xL proteins with Kis of 260±30 nM, 170±10 nM, and 480±40 nM, respectively. (R)-(-)-Gossypol acetic acid (AT-101 (acetic acid)) Chemical Structure
  5. GC35001 (S)-Gossypol acetic acid (S)-Gossypol is the isomer of a natural product Gossypol. (S)-Gossypol binds to the BH3-binding groove of Bcl-xL and Bcl-2 proteins with high affinity. (S)-Gossypol acetic acid Chemical Structure
  6. GC12258 2,3-DCPE hydrochloride 2,3-DCPE hydrochloride Chemical Structure
  7. GC17512 A-1155463 BCL-XL inhibitor, potent and selective A-1155463 Chemical Structure
  8. GC16278 A-1210477 MCL-1 inhibitor A-1210477 Chemical Structure
  9. GC17513 A-1331852 BCL-XL inhibitor, potent and selective A-1331852 Chemical Structure
  10. GC32981 A-385358 A-385358 is a selective inhibitor of Bcl-XL with Kis of 0.80 and 67 nM for Bcl-XL and Bcl-2, respectively. A-385358 Chemical Structure
  11. GC64674 ABBV-167 ABBV-167 is a phosphate prodrug of the BCL-2 inhibitor venetoclax. ABBV-167 Chemical Structure
  12. GC14069 ABT-199 A Bcl-2 inhibitor ABT-199 Chemical Structure
  13. GC12405 ABT-263 (Navitoclax) ABT-263 (Navitoclax) is a inhibitor of Bcl-xL, Bcl-2 and Bcl-w, with Ki ≤0.5 nM, ≤1 nM and ≤1 nM respectively. ABT-263 (Navitoclax) Chemical Structure
  14. GC17234 ABT-737 An inhibitor of anti-apoptotic Bcl-2 proteins ABT-737 Chemical Structure
  15. GN10341 Acetate gossypol Acetate gossypol Chemical Structure
  16. GC19452 AMG-176 AMG-176 (AMG-176) is a potent, selective and orally active MCL-1 inhibitor, with a Ki of 0.13 nM. AMG-176 Chemical Structure
  17. GC14080 Apogossypolone (ApoG2) Apogossypolone (ApoG2) Chemical Structure
  18. GC11106 AT-101 AT-101 Chemical Structure
  19. GC33247 AZD-5991 An Mcl-1 inhibitor AZD-5991 Chemical Structure
  20. GC33283 AZD-5991 Racemate AZD-5991 Racemate is the racemate of AZD-5991. AZD-5991 Racemate is a Mcl-1 inhibitor with an IC50 of <3 nM in FRET assay. AZD-5991 Racemate Chemical Structure
  21. GC33239 AZD-5991 S-enantiomer AZD-5991 S-enantiomer is the less active enantiomer of AZD-5991. AZD-5991 S-enantiomer is a Mcl-1 inhibitor with an IC50 of 6.3 μM in FRET assay and a Kd of 0.98 μM in surface plasmon resonance (SPR) assay. AZD-5991 S-enantiomer Chemical Structure
  22. GC33255 AZD4320 AZD4320 is a novel BH3-mimicking dual BCL2/BCLxL inhibitor with IC50s of 26 nM, 17 nM, and 170 nM for KPUM-MS3, KPUM-UH1, and STR-428 cells, respectively. AZD4320 Chemical Structure
  23. GC34263 Bak BH3 Bak BH3 is derived from the BH3 domain of Bak, can antagonize the function of Bcl-xL in cells. Bak BH3 Chemical Structure
  24. GC12053 BAM7 A direct activator of Bax BAM7 Chemical Structure
  25. GC12763 Bax channel blocker Bax channel blocker Chemical Structure
  26. GC16023 Bax inhibitor peptide P5 Bax inhibitor Bax inhibitor peptide P5 Chemical Structure
  27. GC17195 Bax inhibitor peptide V5 A Bax inhibitor Bax inhibitor peptide V5 Chemical Structure
  28. GC16695 Bax inhibitor peptide, negative control Peptide inhibit Bax translocation to mitochondria Bax inhibitor peptide, negative control Chemical Structure
  29. GC63325 Bcl-xL antagonist 2 Bcl-xL antagonist 2 is a potent, selective, and orally active antagonist of BCL-XL with an IC50 and Ki of 0.091 μM and 65 nM, respectively. Bcl-xL antagonist 2 promotes the apoptosis of cancer cells. Bcl-xL antagonist 2 has the potential for the research of the chronic lymphocytic leukemia (CLL) and non-Hodgkin’s lymphoma (NHL). Bcl-xL antagonist 2 Chemical Structure
  30. GC62599 BCL6-IN-4 BCL6-IN-4 is a potent B-cell lymphoma 6 (BCL6) inhibitor with an IC50 of 97 nM. BCL6-IN-4 has anti-tumor activities. BCL6-IN-4 Chemical Structure
  31. GC68012 BCL6-IN-7 BCL6-IN-7 Chemical Structure
  32. GC10721 BDA-366 BDA-366 is a potent Bcl2 antagonist (Ki = 3.3 nM), binding Bcl2-BH4 domain with high affinity and selectivity. BDA-366 induces conformational change in Bcl2 that abrogates its antiapoptotic function, converting it from a survival molecule to a cell death inducer. BDA-366 suppresses growth of lung cancer cells. BDA-366 Chemical Structure
  33. GC18136 BH3I-1 Bcl-2 or Bcl-XL inhibitor BH3I-1 Chemical Structure
  34. GC15987 BIM, Biotinylated

    Bim peptide fragment with a biotin moiety attached

     BIM, Biotinylated Chemical Structure
  35. GC33407 BM 957 BM 957 is a potent Bcl-2 and Bcl-xL inhibitor, with Kis of 1.2, <1 nM and IC50s of 5.4, 6.0 nM respectively. BM 957 Chemical Structure
  36. GC13498 BM-1074 BM-1074 Chemical Structure
  37. GC62871 BM-1244 BM-1244 (APG-1252-M1) is a potent Bcl-xL/Bcl-2 inhibitor with Kis of 134 and 450 nM for Bcl- xL and Bcl-2, respectively. BM-1244 inhibits senescent fibroblasts (SnCs) with an EC50 of 5 nM. (From patent WO2019033119A1). BM-1244 Chemical Structure
  38. GC38014 BT2 An Mcl-1 inhibitor BT2 Chemical Structure
  39. GC31806 Bz 423 (BZ48) Bz 423 (BZ48) is a pro-apoptotic 1,4-benzodiazepine with therapeutic properties in murine models of lupus demonstrating selectivity for autoreactive lymphocytes, and activates Bax and Bak. Bz 423 (BZ48) Chemical Structure
  40. GC62561 CCT369260 CCT369260 (compound 1) is an orally avtive B-cell lymphoma 6 (BCL6) inhibitor with anti-tumor activity. CCT369260 (compound 1) exhibits an IC50 of 520 nM. CCT369260 Chemical Structure
  41. GN10463 Chelerythrine Chelerythrine Chemical Structure
  42. GC13065 Chelerythrine Chloride Potent inhibitor of PKC and Bcl-xL Chelerythrine Chloride Chemical Structure
  43. GN10219 Ciwujianoside-B Ciwujianoside-B Chemical Structure
  44. GC60111 Clitocine Clitocine, an adenosine nucleoside analog isolated from mushroom, is a potent and efficacious readthrough agent. Clitocine acts as a suppressor of nonsense mutations and can induce the production of p53 protein in cells harboring p53 nonsense-mutated alleles. Clitocine can induce apoptosis in multidrug-resistant human cancer cells by targeting Mcl-1. Anticancer activity. Clitocine Chemical Structure
  45. GN10040 Dehydrocorydaline Dehydrocorydaline Chemical Structure
  46. GC10661 Destruxin B insecticidal and phytotoxic activity;induces apoptosis Destruxin B Chemical Structure
  47. GC38617 Dihydrokaempferol A flavone with diverse biological activities Dihydrokaempferol Chemical Structure
  48. GC35882 dMCL1-2 dMCL1-2 is a potent and selective PROTAC of myeloid cell leukemia 1 (MCL1) (Bcl-2 family member) based on Cereblon, which binds to MCL1 with a KD of 30 nM. dMCL1-2 activats the cellular apoptosis machinery by degradation of MCL1. dMCL1-2 Chemical Structure
  49. GC12139 Gambogic Acid A xanthonoid with anticancer activity Gambogic Acid Chemical Structure
  50. GC32998 Ginsenoside Rh4 Ginsenoside Rh4 Chemical Structure
  51. GC34134 Glycocholic acid A glycine-conjugated form of cholic acid Glycocholic acid Chemical Structure
  52. GN10082 Gossypol Gossypol Chemical Structure
  53. GC11510 HA14-1 A Bcl-2 inhibitor HA14-1 Chemical Structure
  54. GC12046 iMAC2 iMAC2 Chemical Structure
  55. GN10645 Jaceosidin Jaceosidin Chemical Structure
  56. GC64467 Lisaftoclax Lisaftoclax (compound 6) is a dual Bcl-2 and Bcl-xl inhibitor with anti-tumor activity, extracted from patent WO2018027097A1. Lisaftoclax exhibits IC50 values of 2 nM and 5.9 nM for Bcl-2 and Bcl-xl, respectively. Lisaftoclax Chemical Structure
  57. GC15480 Marinopyrrole A Marinopyrrole A (Marinopyrrole A) is a novel and specific Mcl-1 inhibitor with an IC50 value of 10.1 μM, and shows >8 fold selectivity than BCL-xl (IC50 > 80 μM). Marinopyrrole A Chemical Structure
  58. GC66017 Mcl-1 inhibitor 6 Mcl-1 inhibitor 6 is an orally active, selective myeloid cell leukemia 1 (Mcl-1) protein inhibitor with a Kd of 0.23 nM and a Ki of 0.02 μM. Mcl-1 inhibitor 6 possesses superior selectivity over other Bcl-2 family members (Bcl-2, Bcl2A1, Bcl-xL, and Bcl-w, Kd>10 μM). Mcl-1 inhibitor 6 is a potent antitumor agent. Mcl-1 inhibitor 6 Chemical Structure
  59. GC38927 MCL-1/BCL-2-IN-2 MCL-1/BCL-2-IN-2 (Compound 6) is a potent and selective Mcl-1 and Bcl-2 dual inhibitor. MCL-1/BCL-2-IN-2 Chemical Structure
  60. GC38928 MCL-1/BCL-2-IN-3 MCL-1/BCL-2-IN-3 (Compound 2) is a potent and selective Mcl-1 and Bcl-2 dual inhibitor with IC50s of 5.95 and 4.78 μM, respectively. MCL-1/BCL-2-IN-3 Chemical Structure
  61. GC36556 Mcl1-IN-1 Mcl1-IN-1 is an inhibitor of myeloid cell factor 1 (Mcl-1) (IC50=2.4 ?M). Mcl1-IN-1 Chemical Structure
  62. GC36557 Mcl1-IN-11 Mcl1-IN-11 (Compound G) is a selective Mcl-1 inhibitor, less potent at Bcl-2, with Kis of 0.06 and 4.2 μM, respectively. Mcl1-IN-11 Chemical Structure
  63. GC36558 Mcl1-IN-12 Mcl1-IN-12 (Compound F) is a selective Mcl-1 inhibitor, less potent at Bcl-2, with Kis of 0.29 and 3.1 μM, respectively. Anti-tumor activity. Mcl1-IN-12 Chemical Structure
  64. GC33035 Mcl1-IN-2 Mcl1-IN-2 is an inhibitor of myeloid cell factor 1 (Mcl-1). Mcl1-IN-2 is a non-competitive Delhi metallo-β-lactamase (NDM-1) inhibitor. The IC50s of Mcl1-IN-2 against metallo-β-lactamases NDM-1, IMP-4, ImiS and L1 are 0.4637 μM, 3.980 μM, 0.2287 μM and 1.158 μM, respectively. Mcl1-IN-2 Chemical Structure
  65. GC33347 Mcl1-IN-3 Mcl1-IN-3 is an inhibitor of Mcl1 extracted from patent WO2015153959A2, compound example 57; has an IC50 and Ki of 0.67 and 0.13 μM, respectively. Mcl1-IN-3 Chemical Structure
  66. GC33364 Mcl1-IN-4 Mcl1-IN-4 is an inhibitor of Mcl1 with an IC50 of 0.2 μM. Mcl1-IN-4 Chemical Structure
  67. GC38811 Mcl1-IN-8 Mcl1-IN-8 (Compound 8) is an orally active Mcl-1-PUMA interface inhibitor, with a Ki of 0.3 μM. Mcl1-IN-8 exhibits dual activity on reduce PUMA-dependent apoptosis while deactivating Mcl-1-mediated anti-apoptosis in cancer cells. Mcl1-IN-8 Chemical Structure
  68. GC36559 Mcl1-IN-9 Mcl1-IN-9 is a potent myeloid cell leukemia-1 (Mcl-1) Inhibitor with an IC50 of 446 nM in reengineered BCR-ABL+ B-ALL cells and a Ki of 0.03 nM. Mcl1-IN-9 Chemical Structure
  69. GC33295 MIK665 (S-64315) MIK665 (S-64315) (S-64315), derived from S63845, is a myeloid cell leukemia sequence 1 (MCL1) inhibitor. MIK665 (S-64315) has an IC50 of 1.81 nM for MCL1. MIK665 (S-64315) Chemical Structure
  70. GC15400 MIM1 An Mcl-1 inhibiting molecule MIM1 Chemical Structure
  71. GC33312 ML311 An Mcl-1 inhibitor ML311 Chemical Structure
  72. GC61096 MSN-125 MSN-125 is a potent Bax and Bak oligomerization inhibitor. MSN-125 prevents mitochondrial outer membrane permeabilization (MOMP) with an IC50 of 4 μM. MSN-125 potently inhibits Bax/Bak-mediated apoptosis in HCT-116, BMK Cells, and primary cortical neurons, protects primary neurons against glutamate excitotoxicity. MSN-125 Chemical Structure
  73. GC63083 MSN-50 MSN-50 is a Bax and Bak oligomerization inhibitor. MSN-50 Chemical Structure
  74. GC16938 Muristerone A An ecdysteroid receptor agonist Muristerone A Chemical Structure
  75. GC62707 Murizatoclax Murizatoclax (AMG 397) is a potent, selective and orally active inhibitor of myeloid leukemia 1 (MCL-1) inhibitor, with a Ki of 15 pM. Murizatoclax competitive binds to the BH3-binding groove of MCL1 with pro-apoptotic BCL-2 family members. Murizatoclax can be used for the research of cancer. Murizatoclax Chemical Structure
  76. GC68019 NPB NPB Chemical Structure
  77. GC25673 Obatoclax (GX15-070) Obatoclax (GX15-070) Chemical Structure
  78. GC11569 Obatoclax mesylate (GX15-070) An antagonist of pro-survival Bcl-2 proteins Obatoclax mesylate (GX15-070) Chemical Structure
  79. GC36855 Paris saponin VII Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii Maxim. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia. Paris saponin VII Chemical Structure
  80. GC62505 Pelcitoclax Pelcitoclax (APG-1252) is a potent Bcl-2/Bcl-xl inhibitor with antineoplastic and pro-apoptotic effects. Pelcitoclax Chemical Structure
  81. GC63769 PROTAC Bcl-xL degrader-2 PROTAC Bcl-xL degrader-2 is a potent Bcl-xL (Bcl-2 family member) degrader based on von Hippel-Lindau ligand, with an IC50 of 0.6 nM. PROTAC Bcl-xL degrader-2 Chemical Structure
  82. GC38941 PROTAC Bcl2 degrader-1 PROTAC Bcl2 degrader-1 (Compound C5) is a PROTAC based on Cereblon ligand, which potently and selectively induces the degradation of Bcl-2 (IC50, 4.94 μM; DC50, 3.0 μM) and Mcl-1 (IC50, 11.81 μM) by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1. PROTAC Bcl2 degrader-1 Chemical Structure
  83. GC38943 PROTAC Mcl1 degrader-1 PROTAC Mcl1 degrader-1 (compound C3), a proteolysis targeting chimera (PROTAC) based on Cereblon ligand, is a potently and selectively Mcl-1 (Bcl-2 family member) inhibitor with an IC50 of 0.78 μM. PROTAC Mcl1 degrader-1 induces the ubiquitination and proteasomal degradation of Mcl-1 by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1 inhibitor S1-6 with μM-range affinity. PROTAC Mcl1 degrader-1 Chemical Structure
  84. GC34389 PUMA BH3 PUMA BH3 is a p53 upregulated modulator of apoptosis (PUMA) BH3 domain peptide, acts as a direct activator of Bak, with a Kd of 26 nM. PUMA BH3 Chemical Structure
  85. GC12902 Pyridoclax Mcl-1 inhibitor Pyridoclax Chemical Structure
  86. GC11140 Radotinib(IY-5511) Bcr-Abl tyrosine kinase inhibitor Radotinib(IY-5511) Chemical Structure
  87. GC32947 S55746 (BLC201) S55746 (BLC201) (BCL201) is a potent, orally active and selective BCL-2 inhibitor, with a Ki of 1.3 nM and a Kd of 3.9 nM. S55746 (BLC201) (BCL201) has antitumor activity with low toxicity. S55746 (BLC201) Chemical Structure
  88. GC33401 S55746 hydrochloride (BLC201 (hydrochloride)) S55746 hydrochloride (BLC201 (hydrochloride)) (BCL201 hydrochloride) is a potent, orally active and selective BCL-2 inhibitor, with a Ki of 1.3 nM and a Kd of 3.9 nM. S55746 hydrochloride (BLC201 (hydrochloride)) (BCL201 hydrochloride) has antitumor activity with low toxicity. S55746 hydrochloride (BLC201 (hydrochloride)) Chemical Structure
  89. GC12621 S63845 MCL1 inhibitor S63845 Chemical Structure
  90. GC62554 S65487 S65487 (VOB560), a potent and selective BCL-2 inhibitor, is a prodrug of S55746. S65487 is also active on BCL-2 mutations, such as G101V and D103Y. S65487 has poor affinity with MCL-1, BFL-1 and BCL-XL. S65487 induces apoptosis and has anticaner activities. S65487 Chemical Structure
  91. GC63426 S65487 hydrochloride S65487 (VOB560) hydrochloride, a potent and selective Bcl-2 inhibitor, is a prodrug of S55746. S65487 hydrochloride is also active on BCL-2 mutations, such as G101V and D103Y. S65487 hydrochloride has poor affinity with MCL-1, BFL-1 and BCL-XL. S65487 hydrochloride induces apoptosis and has anticaner activities. S65487 hydrochloride Chemical Structure
  92. GC63531 S65487 sulfate S65487 (VOB560) sulfate, a potent and selective Bcl-2 inhibitor, is a prodrug of S55746. S65487 sulfate is also active on BCL-2 mutations, such as G101V and D103Y. S65487 sulfate has poor affinity with MCL-1, BFL-1 and BCL-XL. S65487 sulfate induces apoptosis and has anticaner activities. S65487 sulfate Chemical Structure
  93. GC10153 Sabutoclax A pan-Bcl-2 inhibitor Sabutoclax Chemical Structure
  94. GC10567 TCPOBOP constitutive androstane receptor (CAR) agonist TCPOBOP Chemical Structure
  95. GC37780 Thevetiaflavone Thevetiaflavone could upregulate the expression of Bcl?2 and downregulate that of Bax and caspase?3. Thevetiaflavone Chemical Structure
  96. GC66021 TP-021 TP-021 (BCL6-IN-8c) is a potent and orally active B-cell lymphoma 6 (BCL6)-corepressor interaction inhibitor with an IC50 of 0.10 μM in cell-free enzyme-linked immunosorbent assay. TP-021 Chemical Structure
  97. GC12649 TW-37 An inhibitor of the Bcl-2 family proteins TW-37 Chemical Structure
  98. GC15805 UMI-77 Mcl-1 inhibitor, novel UMI-77 Chemical Structure
  99. GC70114 Venetoclax-d8

    Venetoclax-d8 is the deuterated form of Venetoclax. Venetoclax (ABT-199; GDC-0199) is a highly efficient, selective and orally effective Bcl-2 inhibitor with a Ki value less than 0.01 nM. Venetoclax can induce autophagy.

     Venetoclax-d8 Chemical Structure
  100. GC33052 VU0661013 VU661013 is a potent and selective MCL-1 inhibitor. VU0661013 Chemical Structure
  101. GC11921 WEHI-539 A selective Bcl-xL inhibitor WEHI-539 Chemical Structure

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