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Home >> Signaling Pathways >> Apoptosis >> IAP

IAP

Inhibitor of apoptosis proteins (IAPs) are a family of antiapoptotic proteins that suppress apoptosis by binding to and inhibiting caspases 3, 7 and/or 9. Members of IAP family are characterized by a novel baculoviral IAP repeat (BIR) domain (approximate 70 amino acids) in which a conserved cysteine and histidine residues (Cx2Cx6Wx3Dx5Hx6C) represents a novel zinc-binding fold. However, not all proteins with BIR domain qualify to be an IAP family member. The ability to suppress apoptosis is required as well. So far, eight members of human IAP family have been identified, which are divided into three classes, including class I (XIAP, cIAP1, cIAP2, ILP2 and MLIAP), class II (NAIP) and class III (SURVIVIN and BRUCE).

Products for  IAP

  1. Cat.No. Product Name Information
  2. GC68231 4-Methylsalicylic acid 4-Methylsalicylic acid Chemical Structure
  3. GC50465 A 410099.1 High affinity XIAP antagonist; active in vivo A 410099.1 Chemical Structure
  4. GC62640 APG-1387 APG-1387, a bivalent SMAC mimetic and an IAP antagonist, blocks the activity of IAPs family proteins (XIAP, cIAP-1, cIAP-2, and ML-IAP). APG-1387 induces degradation of cIAP-1 and XIAP proteins, as well as caspase-3 activation and PARP cleavage, which leads to apoptosis. APG-1387 can be used for the research of hepatocellular carcinoma, ovarian cancer, and nasopharyngeal carcinoma. APG-1387 Chemical Structure
  5. GC32803 ASTX660 ASTX660 is an orally bioavailable dual antagonist of cellular inhibitor of apoptosis protein (cIAP) and X-linked inhibitor of apoptosis protein (XIAP). ASTX660 Chemical Structure
  6. GC17448 AT-406 (SM-406) AT-406 (SM-406) (AT-406) is a potent and orally bioavailable Smac mimetic and an antagonist of IAPs, and it binds to XIAP, cIAP1, and cIAP2 proteins with Ki of 66.4, 1.9, and 5.1 nM, respectively. AT-406 (SM-406) Chemical Structure
  7. GC19050 AZD5582 AZD5582 is a novel class of dimeric Smac mimetics as potent IAP antagonist; binds potently to the BIR3 domains of cIAP1, cIAP2, and XIAP (IC50 = 15, 21, and 15 nM, respectively). AZD5582 Chemical Structure
  8. GC12426 Birinapant (TL32711) An antagonist of cIAP1, cIAP2, and XIAP Birinapant (TL32711) Chemical Structure
  9. GC12333 BV6

    Selective inhibitor of IAP proteins

     BV6 Chemical Structure
  10. GC32781 CUDC-427 (GDC-0917) CUDC-427 (GDC-0917) is a potent second-generation pan-selective IAP antagonist, used for treatment of various cancers. CUDC-427 (GDC-0917) Chemical Structure
  11. GC13163 Embelin A benzoquinone with diverse biological activities Embelin Chemical Structure
  12. GC14451 GDC-0152 An inhibitor of IAPs GDC-0152 Chemical Structure
  13. GC14291 LCL161 A Smac mimetic and inhibitor of IAP family proteins LCL161 Chemical Structure
  14. GC64980 MV1 MV1 is an antagonist of IAP (inhibitor of apoptosis protein), leads to protein knockdown of HaloTag-fused proteins when combined with HaloTag ligand. MV1 Chemical Structure
  15. GC19257 MX69 MX69 is an inhibitor of MDM2/XIAP, used for cancer treatment. MX69 Chemical Structure
  16. GC38545 Polygalacin D Polygalacin D (PGD) is a bioactive compound isolated from Platycodon grandiflorum (Jacq.) with anticancer and anti-proliferative properties.PGD suppresses the expression of the IAP family of proteins including survivin, cIAP-1 and cIAP-2 and blocks the PI3K/Akt pathway by inhibiting the phosphorylation of GSK3β, Akt and the expression of PI3K. Polygalacin D induces apoptosis Polygalacin D Chemical Structure
  17. GC63870 SBP-0636457 SBP-0636457 (SB1-0636457) is a SMAC mimetic, and as an IAP antagonist. SBP-0636457 binds to the BIR-domains of the IAP proteins, with a Ki of 0.27 μM. SBP-0636457 can be used for the research of solid tumors and hematologic cancers. SBP-0636457 Chemical Structure
  18. GC63194 SM-1295 SM-1295 is an inhibitor of apoptosis protein (IAP) antagonist, with Kd values of 3077 nM, 3.2 nM and 9.5 nM for XIAP-BIR3, c-IAP1-BIR3 and c-IAP2-BIR3, respectively. SM-1295 Chemical Structure
  19. GC17167 SM-164 Anticancer agent SM-164 Chemical Structure
  20. GC37649 SM-164 Hydrochloride SM-164 Hydrochloride is a cell-permeable Smac mimetic compound. SM-164 binds to XIAP protein containing both the BIR2 and BIR3 domains with an IC50 value of 1.39 nM and functions as an extremely potent antagonist of XIAP. SM-164 Hydrochloride Chemical Structure
  21. GC63195 SM-433 SM-433, a Smac mimetic, function as inhibitor of inhibitor of apoptosis proteins (IAPs). SM-433 exhibits strong binding affinity XIAP BIR3 protein with an IC50<1 μM (patent WO2008128171A2). SM-433 Chemical Structure
  22. GC63709 SM-433 hydrochloride SM-433 hydrochlorid, a Smac mimetic, function as inhibitor of inhibitor of apoptosis proteins (IAPs). SM-433 hydrochlorid exhibits strong binding affinity XIAP BIR3 protein with an IC50<1 μM (patent WO2008128171A2). SM-433 hydrochloride Chemical Structure
  23. GC14402 Triptolide Triptolide is a diterpenoid triepoxide extracted from the root of Thunder God Vine, acting as an inhibitor of NF-κB activation. NF-κB is a family of transcription factor protein complexes. Triptolide Chemical Structure
  24. GC16479 UC 112 IAP inhibitor UC 112 Chemical Structure
  25. GC63290 Xevinapant hydrochloride Xevinapant (AT-406) hydrochloride is a potent and orally bioavailable Smac mimetic and an antagonist of the inhibitor of apoptosis proteins (IAPs). Xevinapant hydrochloride binds to XIAP, cIAP1, and cIAP2 proteins with Kis of 66.4, 1.9, and 5.1 nM, respectively. Xevinapant hydrochloride effectively antagonizes XIAP BIR3 protein in a cell-free functional assay, induces rapid degradation of cellular cIAP1 protein, and inhibits cancer cell growth in various human cancer cell lines. Xevinapant hydrochloride is highly effective in induction of apoptosis in xenograft tumors. Xevinapant hydrochloride Chemical Structure
  26. GC68388 XIAP degrader-1 XIAP degrader-1 Chemical Structure
  27. GC13107 YM155 A small molecule survivin suppressant YM155 Chemical Structure

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