MDM2
The murine double minute 2 (MDM2) is a protein encoded by the mdm2 gene that functions as an E3 ubiquitin ligase to ubiquitinate the p53 tumor suppressor and promotes the proteasomal degradation of p53. Human MDM2 protein is a phosphoprotein of 491 amino acids that inherits the E3 ubiquitin ligase activity from its evolutionarily conserved COOH terminal of RING finger domain (Zinc-binding), a common motif in E3 ligases. Human MDM2 protein mediates monomeric ubiquitination on multiple lysine residues mainly in the COOH terminus of p53 and directly inhibits the transcriptional activity of p53 through binding to the NH2 terminal transactivation domain of p53.
Products for MDM2
- Cat.No. Product Name Information
-
GC14154
(±)-Nutlin-3
MDM2 antagonist, potent and selective
- GC12117 JNJ-26854165 (Serdemetan) An antagonist of MDM2 action
- GC11547 MI-773 (SAR405838) MI-773 (SAR405838) (MI-77301), an analog of MI-773, is a highly potent and selective MDM2-p53 interaction inhibitor. MI-773 (SAR405838) binds to MDM2 with a Ki of 0.88 nM. MI-773 (SAR405838) induces apoptosis and has potent antitumor activity.
- GC12701 NSC 207895 (XI-006) An inhibitor of MDMX
- GC13687 NSC 66811 A potent inhibitor of Mdm2-p53 interaction
- GC12508 Nutlin-3b MDM2/p53 inhibitor
- GC17262 Pifithrin-β potent p53 inhibitor
- GC13019 RG7112 An inhibitor of the MDM2-p53 interaction
- GC11594 RG7388 An inhibitor of the MDM2-p53 interaction
- GC12793 RITA (NSC 652287) An inhibitor of the p53-HDM-2 interaction
- GC10022 SP 141 Mdm2 inhibitor
- GC11445 YH239-EE p53-MDM2 antagonist, potent