Other Apoptosis
Products for Other Apoptosis
- Cat.No. Product Name Information
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GC10350
TIC10 isomer
Potent Akt/ERK inhibitor
- GC45213 α-NETA Choline acetyltransferase (ChAT) mediates the synthesis of the neurotransmitter acetylcholine from acetyl-CoA and choline.
- GC46008 (±)-Thalidomide-d4 An internal standard for the quantification of (±)-thalidomide
- GC45256 (+)-ar-Turmerone (+)-ar-Turmerone is an aromatic compound from the rhizomes of C.
- GC41345 (-)-α-Bisabolol (-)-α-Bisabolol ((-)-α-Bisabolol), a monocyclic sesquiterpene alcohol, exerts antioxidant, anti-inflammatory, and anti-apoptotic activities.
- GC40698 (-)-Perillyl Alcohol (-)-Perillyl Alcohol is a monoterpene found in lavender, inhibits farnesylation of Ras, upregulates the mannose-6-phosphate receptor and induces apoptosis. Anti-cancer activity.
- GC34965 (20S)-Protopanaxatriol An active ginsenoside metabolite
- GC34981 (E)-Flavokawain A (E)-Flavokawain A, a chalcone extracted from Kava, has anticarcinogenic effect. (E)-Flavokawain A induces apoptosis in bladder cancer cells by involvement of bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice.
- GC34125 (E)-[6]-Dehydroparadol (E)-[6]-Dehydroparadol, an oxidative metabolite of [6]-Shogaol, is a potent Nrf2 activator. (E)-[6]-Dehydroparadol can inhibit the growth and induce the apoptosis of human cancer cells.
- GN10783 (R) Ginsenoside Rh2
- GC15104 (R)-(+)-Etomoxir sodium salt Etomoxir((R)-(+)-Etomoxir) sodium salt is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid oxidation (FAO) through CPT-1a and inhibits palmitate β-oxidation in human, rat and guinea pig.
- GC41716 (R)-CR8 Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy.
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GC19541
(rac)-Antineoplaston A10
(rac)-Antineoplaston A10 is the racemate of Antineoplaston A10
- GC10098 (S)-10-Hydroxycamptothecin inhibitor of topoisomerase I
- GC11965 (±)-Huperzine A A neuroprotective AChE inhibitor
- GC11988 15-acetoxy Scirpenol mycotoxin that induce apoptotic cell death
- GC11720 17-AAG (KOS953) An inhibitor of Hsp90
- GC13044 17-DMAG (Alvespimycin) HCl 17-DMAG (Alvespimycin) HCl (17-DMAG hydrochloride; KOS-1022; BMS 826476) is a potent inhibitor of Hsp90, binding to Hsp90 with EC50 of 62±29 nM.
- GN10065 2-Atractylenolide
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GC17430
2-Deoxy-D-glucose
2-Deoxy-D-glucose (2DG), is a glucose analogue, act as competitive glycolytic inhibitor.
- GC38318 2-Methoxycinnamaldehyde 2-Methoxycinnamaldehyde (o-Methoxycinnamaldehyde) is a natural compound of Cinnamomum cassia, with antitumor activity. 2-Methoxycinnamaldehyde inhibits proliferation and induces apoptosis by mitochondrial membrane potential (ΔΨm) loss, activation of both caspase-3 and caspase-9. 2-Methoxycinnamaldehyde effectively inhibits platelet-derived growth factor (PDGF)-induced HASMC migration.
- GC15084 2-Methoxyestradiol (2-MeOE2) 2-Methoxyestradiol (2-MeOE2/2-Me) is a HIF-1α inhibitor that inhibits HIF-1α accumulation and HIF transcriptional activity. 2-Methoxyestradiol can trigger p53-induced apoptosis and has potential antitumor activity..
- GN10800 20(S)-NotoginsenosideR2
- GC35112 3'-Hydroxypterostilbene 3'-Hydroxypterostilbene is a Pterostilbene analogue. 3'-Hydroxypterostilbene inhibits the growth of COLO 205, HCT-116 and HT-29 cells with IC50s of 9.0, 40.2 and 70.9 ?M, respectively. 3'-Hydroxypterostilbene significantly down-regulates PI3K/Akt and MAPKs signaling pathways and effectively inhibits the growth of human colon cancer cells by inducing apoptosis and autophagy. 3'-Hydroxypterostilbene can be used for the research of cancer.
- GC35106 3-Dehydrotrametenolic acid 3-?Dehydrotrametenolic acid, isolated from the sclerotium of Poria cocos, is a lactate dehydrogenase (LDH) inhibitor. 3-?Dehydrotrametenolic acid promotes adipocyte differentiation in vitro and acts as an insulin sensitizer in vivo. 3-?Dehydrotrametenolic acid induces apoptosis and has anticancer activity.
- GC17394 3-Nitropropionic acid 3-Nitropropionic acid (β-Nitropropionic acid) is an irreversible inhibitor of succinate dehydrogenase.
- GC35099 3-O-Acetyloleanolic acid 3-O-Acetyloleanolic acid (3AOA), an oleanolic acid derivative isolated from the seeds of Vigna sinensis K., induces in cancer and also exhibits anti-angiogenesis activity.
- GC32767 3BDO A butyrolactone derivative and autophagy inhibitor
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GC42346
4-bromo A23187
4-bromo A23187 is a halogenated analog of the highly selective calcium ionophore A23187.
- GC30896 4-Hydroxybenzyl alcohol A phenol with diverse biological activities
- GC35138 4-Methyldaphnetin 4-Methyldaphnetin is a precursor in the synthesis of derivatives of 4-methyl coumarin. 4-Methyldaphnetin has potent, selective anti-proliferative and apoptosis-inducing effects on several cancer cell lines. 4-Methyldaphnetin possesses radical scavenging property and strongly inhibits membrane lipid peroxidation.
- GC10468 4EGI-1 Competitive eIF4E/eIF4G interaction inhibitor
- GC35150 5,7,4'-Trimethoxyflavone 5,7,4'-Trimethoxyflavone is isolated from Kaempferia parviflora (KP) that is a famous medicinal plant from Thailand. 5,7,4'-Trimethoxyflavone induces apoptosis, as evidenced by increments of sub-G1 phase, DNA fragmentation, annexin-V/PI staining, the Bax/Bcl-xL ratio, proteolytic activation of caspase-3, and degradation of poly (ADP-ribose) polymerase (PARP) protein.5,7,4'-Trimethoxyflavone is significantly effective at inhibiting proliferation of SNU-16 human gastric cancer cells in a concentration dependent manner.
- GC35147 5-(N,N-Hexamethylene)-amiloride An amiloride derivative with diverse biological activities
- GC45356 5-Aminolevulinic Acid (hydrochloride)
- GN10093 6-gingerol
- GC16853 7,8-Dihydroxyflavone Tyrosine kinase receptor B (TrkB) agonist
- GC17119 8-Prenylnaringenin estrogen receptor inhibitor
- GC39152 9-ING-41 9-ING-41 is a maleimide-based ATP-competitive and selective glycogen synthase kinase-3β (GSK-3β) inhibitor with an IC50 of 0.71 μM. 9-ING-41 significantly leads to cell cycle arrest, autophagy and apoptosis in cancer cells. 9-ING-41 has anticancer activity and has the potential for enhancing the antitumor effects of chemotherapeutic drugs.
- GN10035 9-Methoxycamptothecin
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GC11200
A23187
A23187, free acid is a Ca2+ ionophore
- GC35216 AAPK-25 AAPK-25 is a potent and selective Aurora/PLK dual inhibitor with anti-tumor activity, which can cause mitotic delay and arrest cells in a prometaphase, reflecting by the biomarker histone H3Ser10 phosphorylation and followed by a surge in apoptosis. AAPK-25 targets Aurora-A, -B, and -C with Kd values ranging from 23-289 nM, as well as PLK-1, -2, and -3 with Kd values ranging from 55-456 nM.
- GC13805 Abacavir
- GC35227 ACBI1 ACBI1 is a potent and cooperative SMARCA2, SMARCA4 and PBRM1 degrader with DC50s of 6, 11 and 32 nM, respectively. ACBI1 is a PROTAC degrader. ACBI1 shows anti-proliferative activity. ACBI1 induces apoptosis.
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GC11786
Acetylcysteine
Acetylcysteine is the N-acetyl derivative of CYSTEINE.
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GC17094
Acitretin
Metabolite of etretinate
- GC35242 Actein Actein is a triterpene glycoside isolated from the rhizomes of Cimicifuga foetida. Actein suppresses cell proliferation, induces autophagy and apoptosis through promoting ROS/JNK activation, and blunting AKT pathway in human bladder cancer. Actein has little toxicity in vivo.
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GC16350
Actinonin
Peptidomimetic antibiotic that inhibits aminopeptidases
- GC10610 Adapalene RARβ and RARγ agonist
- GC13959 Adarotene An atypical retinoid
- GC11892 AEE788 (NVP-AEE788) AEE788 (NVP-AEE788) is an inhibitor of the EGFR and ErbB2 with IC50 values of 2 and 6 nM, respectively.
- GC13168 AG 825 Selective ErbB2 inhibitor
- GC13697 AG-1024 Selective IGF-1R inhibitor
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GC17881
AGK 2
AGK2 is a selective SIRT2 inhibitor, with an IC50 of 3.
- GC39620 AKOS-22
- GC11589 AKT inhibitor VIII A potent inhibitor of Akt1 and Akt2
- GC35275 AKT-IN-3 AKT-IN-3 (compound E22) is a potent, orally active low hERG blocking Akt inhibitor, with 1.4 nM, 1.2 nM and 1.7 nM for Akt1, Akt2 and Akt3, respectively. AKT-IN-3 (compound E22) also exhibits good inhibitory activity against other AGC family kinases, such as PKA, PKC, ROCK1, RSK1, P70S6K, and SGK. AKT-IN-3 (compound E22) induces apoptosis and inhibits metastasis of cancer cells.
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GC16597
Alda 1
ALDH2 activator
- GC35288 Alkannin A naphthoquinone with diverse biological activities
- GC32127 Alofanib (RPT835) Alofanib (RPT835) (RPT835) is a potent and selective allosteric inhibitor of fibroblast growth factor receptor 2 (FGFR2).
- GC14314 Aloperine An alkaloid
- GC35306 alpha-Mangostin alpha-Mangostin (α-Mangostin) is a dietary xanthone with broad biological activities, such as antioxidant, anti-allergic, antiviral, antibacterial, anti-inflammatory and anticancer effects. It is an inhibitor of mutant IDH1 (IDH1-R132H) with a Ki of 2.85 μM.
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GC42776
Amarogentin
A secoiridoid glycoside with diverse biological activities
- GN10484 Amentoflavone
- GC12051 Amiloride HCl dihydrate Amiloride HCl dihydrate (MK-870 hydrochloride dihydrate) is an inhibitor of both epithelial sodium channel (ENaC[1]) and urokinase-type plasminogen activator receptor (uTPA[2]).
- GC16391 Amuvatinib (MP-470, HPK 56) A multi-targeted RTK inhibitor
- GN10045 Angelicin
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GC11559
Anisomycin
JNK agonist, potent and specific
- GC35361 Antineoplaston A10 Antineoplaston A10, a naturally occurring substance in human body, is a Ras inhibitor potentially for the treatment of glioma, lymphoma, astrocytoma and breast cancer.
- GC15586 AP1903 AP1903 (AP1903) is a dimerizer agent that acts by cross-linking the FKBP domains. AP1903 (AP1903) dimerizes the Caspase 9 suicide switch and rapidly induces apoptosis.
- GC35367 APG-115 APG-115 (APG-115) is an orally active MDM2 protein inhibitor binding to MDM2 protein with IC50 and Ki values of 3.8 nM and 1 nM, respectively. APG-115 blocks the interaction of MDM2 and p53 and induces cell-cycle arrest and apoptosis in a p53-dependent manner.
- GC16237 Apocynin Selective NADPH-oxidase inhibitor
- GC14209 Apoptosis Activator 2 An activator of caspases
- GC14411 Apoptozole inhibitor of heat shock protein 70 (Hsp70)
- GC10420 Apremilast (CC-10004) An orally available PDE4 inhibitor
- GC32692 APTO-253 (LOR-253) APTO-253 (LOR-253) (LOR-253) is a small molecule that inhibits c-Myc expression, stabilizes G-quadruplex DNA, and induces cell cycle arrest and apoptosis in acute myeloid leukemia cells.
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GC14590
AR-42 (OSU-HDAC42)
HDAC inhibitor,novel and potent
- GC19037 ARS-853 ARS-853 is a selective, covalent KRASG12C inhibitor with an IC50 of 2.5 uM.
- GC12070 Ascorbic acid An electron donor
- GN10702 Asiatic acid
- GN10534 Asiaticoside
- GC19041 ASK1-IN-1 ASK1-IN-1 is a potent, orally available and selective ATP-competitive inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with an IC50 of 2.87 nM.
- GN10064 Asperosaponin VI
- GN10561 astragalin
- GC18109 Astragaloside A anti-hypertension, positive inotropic action, anti-inflammation, and anti-myocardial injury
- GC35415 Astramembrangenin
- GC15870 AT7519 Multi-CDK inhibitor
- GC13998 AT7519 Hydrochloride A Cdk inhibitor
- GC10638 AT9283 A broad spectrum kinase inhibitor
- GC18133 ATB-346 ATB-346 (ATB-346), an orally active non-steroidal anti-inflammatory drug (NSAID), inhibits cyclooxygenase-1 and 2 (COX-1 and 2).
- GN10394 Atractylenolide III
- GC13332 Aurora A Inhibitor I A potent and selective inhibitor of Aurora A kinase
- GC15295 AUY922 (NVP-AUY922) An Hsp90 inhibitor
- GC17045 AXL1717 A potent and selective inhibitor of IGF-1R
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GC15055
AZ 628
Raf kinases,potent and ATP-competitive
- GC13433 AZ 960 A JAK2 inhibitor
- GC15033 Azathioprine purine synthesis and GTP-binding protein Rac1 activation inhibitor
- GC12660 AZD1208 A pan-Pim kinase inhibitor
- GC13029 AZD2014 AZD2014 (AZD2014) is an ATP competitive mTOR inhibitor with an IC50 of 2.81 nM. AZD2014 inhibits both mTORC1 and mTORC2 complexes.
- GC16380 AZD8055 MTOR inhibitor